Evidence map›Paper›PMID 22010921›Full record

ArticleThe New England journal of medicine2011

When to start antiretroviral therapy in HIV-associated tuberculosis.

M Estée Török, Jeremy J Farrar

Registry-linked trialAbstract readEditorialComment
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03092817 (A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03092817 phase3completednot on this mapstarted 2017, after this paper: background citation

A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis

TypeinterventionalSponsorOxford University Clinical Research Unit, VietnamRan2017 to 2023Enrolled520ConditionsTuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIVArmsDexamethasone, Placebo
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Clinical Outcomes of Patients With Drug-Resistant Tuberculous Meningitis Treated With an Intensified Antituberculosis Regimen.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Trial
  5. Article
  6. Article
  7. Global HIV neurology: a comprehensive review.AIDS (London, England) · 2019
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Risk factors for mortality in Malawian children with human immunodeficiency virus and tuberculosis co-infection.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2013
    Article
  13. Article
  14. Article
  15. Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

M Estée Török
Jeremy J Farrar

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HIV-1AIDS-Related Opportunistic InfectionsAnti-Retroviral AgentsAntitubercular AgentsFemaleHIV InfectionsHumansMaleTuberculosisAnti-Retroviral AgentsAntitubercular Agents

Identifiers

PMID22010921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.