ReviewMetal ions in life sciences2011
The roles of metal ions in regulation by riboswitches.
Review in Metal ions in life sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Population-level control of two manganese oxidases expands the niche for bacterial manganese biomineralization.NPJ biofilms and microbiomes · 2025Article
- Systematic Model Peptide Studies: A Crucial Step To Understand the Coordination Chemistry of Mn(II) and Fe(II) in Proteins.Inorganic chemistry · 2025Article
- Deciphering ligand and metal ion dependent intricate folding landscape of Vc2 c-di-GMP riboswitch aptamer.Nucleic acids research · 2025Article
- Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA.Nucleic acids research · 2022Article
- Key players in regulatory RNA realm of bacteria.Biochemistry and biophysics reports · 2022Review
- Cooperativity and Interdependency between RNA Structure and RNA-RNA Interactions.Non-coding RNA · 2021Review
- The role of solute binding proteins in signal transduction.Computational and structural biotechnology journal · 2021Review
- A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation.RNA (New York, N.Y.) · 2020Article
- Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators.Cell chemical biology · 2018Article
- Regulatory RNA in Mycobacterium tuberculosis, back to basics.Pathogens and disease · 2018Review
- The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations.International journal of molecular sciences · 2016Article
- Screening and Identifying a Novel ssDNA Aptamer against Alpha-fetoprotein Using CE-SELEX.Scientific reports · 2015Article
- Review
- In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bacterial riboswitches cooperatively bind Ni(2+) or Co(2+) ions and control expression of heavy metal transporters.Molecular cell · 2015Article
- Dramatic improvement of crystals of large RNAs by cation replacement and dehydration.Structure (London, England : 1993) · 2014Article
- Nucleic acid catalysis: metals, nucleobases, and other cofactors.Chemical reviews · 2014Review
- Genetic analysis of riboswitch-mediated transcriptional regulation responding to Mn2+ in Salmonella.The Journal of biological chemistry · 2014Article
- Mg(2+)-induced conformational changes in the btuB riboswitch from E. coli.RNA (New York, N.Y.) · 2014Article
- Comparative genomics of metabolic capacities of regulons controlled by cis-regulatory RNA motifs in bacteria.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Metal ions are required by all organisms in order to execute an array of essential molecular functions. They play a critical role in many catalytic mechanisms and structural properties. Proper homeostasis of ions is critical; levels that are aberrantly low or high are deleterious to cellular physiology. To maintain stable intracellular pools, metal ion-sensing regulatory (metalloregulatory) proteins couple metal ion concentration fluctuations with expression of genes encoding for cation transport or sequestration. However, these transcriptional-based regulatory strategies are not the only mechanisms by which organisms coordinate metal ions with gene expression. Intriguingly, a few classes of signal-responsive RNA elements have also been discovered to function as metalloregulatory agents. This suggests that RNA-based regulatory strategies can be precisely tuned to intracellular metal ion pools, functionally akin to metal-loregulatory proteins. In addition to these metal-sensing regulatory RNAs, there is a yet broader role for metal ions in directly assisting the structural integrity of other signal-responsive regulatory RNA elements. In this chapter, we discuss how the intimate physicochemical relationship between metal ions and nucleic acids is important for the structure and function of metal ion- and metabolite-sensing regulatory RNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.