ArticleCirculation. Cardiovascular genetics2011
Genomes, proteomes, and the central dogma.
Article in Circulation. Cardiovascular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Multi‑omics insights into uveitis: From mechanisms to precision medicine (Review).International journal of molecular medicine · 2026Review
- Screening for Heart Failure: Biomarkers to Detect Heightened Risk in the General Population.Current heart failure reports · 2024Review
- Epigenetic Regulation of Autophagy in Bone Metabolism.Function (Oxford, England) · 2024Review
- Characterization of TFIIE-regulated genes by transcriptome analysis.Turkish journal of biology = Turk biyoloji dergisi · 2024Article
- Pharmacometabolomics of Asthma as a Road Map to Precision Medicine.Handbook of experimental pharmacology · 2023Article
- Using Omics to Study Leprosy, Tuberculosis, and Other Mycobacterial Diseases.Frontiers in cellular and infection microbiology · 2022Review
- Etodolac improves collagen induced rheumatoid arthritis in rats by inhibiting synovial inflammation, fibrosis and hyperplasia.Molecular biomedicine · 2021Article
- Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations.Clinical epigenetics · 2021Article
- Omics-Facilitated Crop Improvement for Climate Resilience and Superior Nutritive Value.Frontiers in plant science · 2021Review
- Resolving Chemical Modifications to a Single Amino Acid within a Peptide Using a Biological Nanopore.ACS nano · 2019Article
- Long non-coding RNA ZNF674-1 acts as a cancer suppressor in nasopharyngeal carcinoma.Oncology letters · 2018Article
- Precision medicine for disease modification in Parkinson disease.Nature reviews. Neurology · 2017Review
- Nature's Electric Potential: A Systematic Review of the Role of Bioelectricity in Wound Healing and Regenerative Processes in Animals, Humans, and Plants.Frontiers in physiology · 2017Review
- Identification of functional modules by integration of multiple data sources using a Bayesian network classifier.Circulation. Cardiovascular genetics · 2014Article
- Integrative physiology and systems biology: reductionism, emergence and causality.Extreme physiology & medicine · 2013Article
- Structural considerations for chromatin state models with transcription as a functional readout.FEBS letters · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Systems biology, with its associated technologies of proteomics, genomics, and metabolomics, is driving the evolution of our understanding of cardiovascular physiology. Rather than studying individual molecules or even single reactions, a systems approach allows integration of orthogonal data sets from distinct tiers of biological data, including gene, RNA, protein, metabolite, and other component networks. Together these networks give rise to emergent properties of cellular function, and it is their reprogramming that causes disease. We present 5 observations regarding how systems biology is guiding a revisiting of the central dogma: (1) It deemphasizes the unidirectional flow of information from genes to proteins; (2) it reveals the role of modules of molecules as opposed to individual proteins acting in isolation; (3) it enables discovery of novel emergent properties; (4) it demonstrates the importance of networks in biology; and (5) it adds new dimensionality to the study of biological systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.