ArticleThe Plant cell2011
Interplay between N-terminal methionine excision and FtsH protease is essential for normal chloroplast development and function in Arabidopsis.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Rubisco functional integrity requires a dedicated three-step maturation pathway.Science advances · 2026Article
- Chloroplast ATP synthase: From structure to engineering.The Plant cell · 2024Review
- STIC2 selectively binds ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteins.The EMBO journal · 2024Article
- ER-associated VAP27-1 and VAP27-3 proteins functionally link the lipid-binding ORP2A at the ER-chloroplast contact sites.Nature communications · 2024Article
- Cloning and functional characterization of the peptide deformylase encoding gene EuPDF1B from Eucommia ulmoides Oliv.Scientific reports · 2024Article
- Article
- Transcriptome analysis ofJournal of ginseng research · 2020Article
- The chloroplast metalloproteases VAR2 and EGY1 act synergistically to regulate chloroplast development in Arabidopsis.The Journal of biological chemistry · 2020Article
- Chloroplast Translation Elongation Factor EF-Tu/SVR11 Is Involved inFrontiers in plant science · 2019Article
- TGNap1 is required for microtubule-dependent homeostasis of a subpopulation of the plant trans-Golgi network.Nature communications · 2018Article
- Differential Roles of the Thylakoid Lumenal Deg Protease Homologs in Chloroplast Proteostasis.Plant physiology · 2018Article
- Comparative proteomic analysis of QTL CTS-12 derived from wild rice (Oryza rufipogon Griff.), in the regulation of cold acclimation and de-acclimation of rice (Oryza sativa L.) in response to severe chilling stress.BMC plant biology · 2018Article
- Targeted Profiling ofThe Plant cell · 2018Article
- FtsH Protease in the Thylakoid Membrane: Physiological Functions and the Regulation of Protease Activity.Frontiers in plant science · 2018Review
- Balance between Cytosolic and Chloroplast Translation Affects Leaf Variegation.Plant physiology · 2018Article
- Chloroplast Proteases: Updates on Proteolysis within and across Suborganellar Compartments.Plant physiology · 2016Review
- Testing the Role of the N-Terminal Tail of D1 in the Maintenance of Photosystem II in Tobacco Chloroplasts.Frontiers in plant science · 2016Article
- Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.The Journal of cell biology · 2015Article
- Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control.Microbial cell (Graz, Austria) · 2015Article
- Leaf Variegation of Thylakoid Formation1 Is Suppressed by Mutations of Specific σ-Factors in Arabidopsis.Plant physiology · 2015Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-terminal methionine excision (NME) is the earliest modification affecting most proteins. All compartments in which protein synthesis occurs contain dedicated NME machinery. Developmental defects induced in Arabidopsis thaliana by NME inhibition are accompanied by increased proteolysis. Although increasing evidence supports a connection between NME and protein degradation, the identity of the proteases involved remains unknown. Here we report that chloroplastic NME (cNME) acts upstream of the FtsH protease complex. Developmental defects and higher sensitivity to photoinhibition associated with the ftsh2 mutation were abolished when cNME was inhibited. Moreover, the accumulation of D1 and D2 proteins of the photosystem II reaction center was always dependent on the prior action of cNME. Under standard light conditions, inhibition of chloroplast translation induced accumulation of correctly NME-processed D1 and D2 in a ftsh2 background, implying that the latter is involved in protein quality control, and that correctly NME-processed D1 and D2 are turned over primarily by the thylakoid FtsH protease complex. By contrast, inhibition of cNME compromises the specific N-terminal recognition of D1 and D2 by the FtsH complex, whereas the unprocessed forms are recognized by other proteases. Our results highlight the tight functional interplay between NME and the FtsH protease complex in the chloroplast.
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