ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2012
Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation.International journal of molecular sciences · 2024Article
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.Nature communications · 2022Article
- Article
- Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Activity-Dependent Gene Expression in the Mammalian Olfactory Epithelium.Chemical senses · 2017Review
- Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury.PloS one · 2016Article
- The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Activity-dependent genes in mouse olfactory sensory neurons.Chemical senses · 2014Article
- MeCP2 is required for activity-dependent refinement of olfactory circuits.Molecular and cellular neurosciences · 2014Article
- Spontaneous and sensory-evoked activity in mouse olfactory sensory neurons with defined odorant receptors.Journal of neurophysiology · 2013Article
- Dendritic branch intersections are structurally regulated targets for efficient axonal wiring and synaptic clustering.PloS one · 2013Article
- Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance.Neural development · 2012Article
- Studies of olfactory system neural plasticity: the contribution of the unilateral naris occlusion technique.Neural plasticity · 2012Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the identities and functions of extracellular signaling molecules that work in concert with neuronal activity to regulate refinement and maintenance of the mouse olfactory sensory map. We show that expression of a dominant negative retinoic acid receptor (RAR) in olfactory sensory neurons (OSNs) increased the number of glomeruli that incorrectly contained OSN axons expressing different odorant receptors. This phenotype became apparent postnatally, coincided with increased cell death, and was preceded by increased Neuropilin-1 and reduced Kirrel-2 expressions. Kirrel-2-mediated cell adhesion influences odorant receptor-specific axonal convergence and is regulated by odorant receptor signaling via the olfactory cyclic nucleotide-gated (CNG) ion channel. Accordingly, we found that inhibited RAR function correlated with reduced CNG channel expression. Naris occlusion experiments and analysis of CNG channel-deficient mice further indicated that RAR-regulated CNG channel levels influenced the intrinsic neuronal activity required for cell survival in the absence of odor stimulation. Finally, we showed that CNG channel activity regulated expression of the retinoic acid-degrading enzyme Cyp26B1. Combined, these results identify a novel homeostatic feedback mechanism involving retinoic acid metabolism and CNG channel activity, which influences glomerular homogeneity and maintenance of precisely connected OSNs.
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