Trial reportHead & neck2012
Phase II trial of induction chemotherapy followed by surgery for squamous cell carcinoma of the oral tongue in young adults.
Trial report in Head & neck, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02985255 (Role of Neo-adjuvant Chemotherapy in Organ Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Neo-adjuvant Chemotherapy in Organ Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Prognostic factors in young patients with oral cavity cancer: a systematic review and meta-analysis of 24 studies.Frontiers in oncology · 2026Pooled it
- Neoadjuvant PD-1/PD-L1 Inhibitors for Resectable Head and Neck Cancer: A Systematic Review and Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2021Pooled it
- A systematic review and meta-analysis of the prognostic role of age in oral tongue cancer.Cancer medicine · 2021Pooled it
- Nonsurgical management of resectable oral cavity cancer in the wake of COVID-19: A rapid review and meta-analysis.Oral oncology · 2020Pooled it
- Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Trial
- Assessment methods of pathological complete response in neoadjuvant head and neck cancer clinical trials: a scoping review.The journal of pathology. Clinical research · 2026Article
- Ribophorin II Overexpression Is Associated with Poor Response to Induction Chemotherapy with Docetaxel, Cisplatin, and Fluorouracil in P16-Negative Locally Advanced Head and Neck Squamous Cell Carcinoma.Journal of clinical medicine · 2021Article
- Survival Outcomes in Oral Tongue Cancer: A Mono-Institutional Experience Focusing on Age.Frontiers in oncology · 2021Article
- The oncological outcome and influence of neoadjuvant chemotherapy on the surgery in the resectable and locally advanced oral squamous cell carcinoma.Cancer management and research · 2019Article
- Post-glossectomy in lingual carcinomas: a scope for sign language in rehabilitation.Contemporary oncology (Poznan, Poland) · 2017Review
- Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil.World journal of surgical oncology · 2016Article
- Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients.Cancer research · 2015Article
- Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature.Radiology and oncology · 2014Review
- Oral tongue squamous cell carcinoma in young women: a matched comparison-do outcomes justify treatment intensity?ISRN otolaryngology · 2014Article
- Methylation-mediated molecular dysregulation in clinical oral malignancy.Journal of oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe conducted a phase II clinical trial of induction chemotherapy followed by surgery ± radiotherapy for squamous cell carcinoma of the oral tongue (SCCOT) in young adults.
methodsFrom September 2001 to October 2004, 23 patients aged 18 to 49 years with clinical T2-3 N0-2 M0 SCCOT and no prior radiotherapy, chemotherapy, or neck dissection underwent induction chemotherapy (paclitaxel, ifosfamide, and carboplatin) followed by glossectomy and neck dissection ± radiotherapy and chemotherapy.
resultsOn final surgical pathology, 9 patients (39%) had a complete/major (2 complete) histologic response at the primary tumor site; 8 patients (35%) had no response or progression. Similarly, 9 patients (39%) had a complete response in the neck or remained node negative; 6 patients (26%) had an increase in nodal category. No treatment-associated deaths occurred, and toxicity was modest. At a median follow-up from the end of treatment of 52 months (minimum, 23 months), 10 patients (43%) developed recurrence, and all 10 died of cancer. Crude recurrence/cancer death rates were associated with ≤ a partial response at the tongue (p = .029), poor histologic differentiation (p = .012), and multiple adverse features on final surgical pathology (p = .040).
conclusionResponse rates and overall survival with this induction chemotherapy regimen were limited, but complete/major response at the tongue was associated with excellent prognosis. Additionally, improved patient selection and predictive tumor biomarkers will be needed for induction chemotherapy to be routinely incorporated into the treatment of oral tongue cancer in young adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.