ArticleThe Journal of biological chemistry2011
Regulation of oocyte and cumulus cell interactions by intermedin/adrenomedullin 2.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Heat Shock Affects Amino Acid Metabolism in Bovine Cumulus Cells and Denuded Oocytes During In Vitro Maturation.Biology · 2026Article
- Expression and regulation of adrenomedullin 2 gene in ovarian follicles and its effect on follicular granulosa cells in chicken.Poultry science · 2025Article
- Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells by Decreasing ADM2 Expression in Patients with PCOS.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Editorial: Small molecules and peptides in paracrine/autocrine regulation of ovarian folliculogenesis.Frontiers in endocrinology · 2023Article
- IMD/ADM2 operates as a secretory factor that controls cumulus-oocyte complexes (COCs) conformation for oocytes in vitro maturation.In vitro cellular & developmental biology. Animal · 2022Article
- Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation.Frontiers in endocrinology · 2022Article
- Identification of genes involved in chicken follicle selection by ONT sequencing on granulosa cells.Frontiers in genetics · 2022Article
- Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Follicular Fluid Levels of Adrenomedullin 2, Vascular Endothelial Growth Factor and its Soluble Receptors Are Associated with Ovarian Response During ART Cycles.Geburtshilfe und Frauenheilkunde · 2019Article
- Urea influences amino acid turnover in bovine cumulus-oocyte complexes, cumulus cells and denuded oocytes, and affects in vitro fertilization outcome.Scientific reports · 2018Article
- PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice.EMBO molecular medicine · 2018Article
- Mechanisms controlling germline cyst breakdown and primordial follicle formation.Cellular and molecular life sciences : CMLS · 2017Review
- Biobanking of different body fluids within the frame of IVF-a standard operating procedure to improve reproductive biology research.Journal of assisted reproduction and genetics · 2017Article
- Adrenomedullin2 (ADM2)/intermedin (IMD) in rat ovary: changes in estrous cycle and pregnancy and its role in ovulation and steroidogenesis.Biology of reproduction · 2015Article
- Proteomic analysis of human follicular fluid from fertile women.Clinical proteomics · 2015Article
- Roles of CLR/RAMP receptor signaling in reproduction and development.Current protein & peptide science · 2013Review
- Intermedin in rat uterus: changes in gene expression and peptide levels across the estrous cycle and its effects on uterine contraction.Reproductive biology and endocrinology : RB&E · 2013Article
- Article
- Regulation and 3 dimensional culture of tertiary follicle growth.Clinical and experimental reproductive medicine · 2012Article
- Insights into female germ cell biology: from in vivo development to in vitro derivations.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Ovarian folliculogenesis has been studied as a model of hormonal regulation of development and differentiation, cell death, and cell-cell communication. In addition to gonadotropins from the pituitary and follicular paracrine factors, oocyte secreted factors have been shown to play critical roles in the regulation of follicular cell functions. Except for the well characterized BMP family proteins, including GDF9 and BMP15, oocytes are known to secrete oocyte secreted factors that are important for the regulation of cumulus cell survival and the maintenance of tertiary structure of cumulus cell-enclosed oocyte complexes (COCs). Based on genomic screening and studies of COCs cultured in vitro, we showed that intermedin (IMD)/adrenomedullin 2 (ADM2) is a novel oocyte-derived ligand important for the regulation of cell interactions in COCs that functions, in part, by suppressing cumulus cell apoptosis. Consistently, we showed that suppression of IMD/ADM2 signaling in growing rat ovaries in vivo leads to oocyte atresia and aberrant cell cycle progression in follicular cells. Together, our studies indicated that mammalian oocytes deploy a G protein-coupled receptor ligand to coordinate normal interactions of oocytes and cumulus cells and provided a better understanding of how the tertiary structure of a COC is maintained as follicles undergo exponential growth during the late stages of folliculogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.