Evidence map›Paper›PMID 22009721›Full record

ArticleMagnetic resonance in medicine2012

3D magnetic resonance microscopy of the ex vivo retina.

Bryan H De La Garza, Eric R Muir, Yen-Yu I Shih, Timothy Q Duong

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bryan H De La GarzaUniversity of Texas Health Science Center, San Antonio, TX, USA.
Eric R Muir
Yen-Yu I Shih
Timothy Q Duong
The University of Texas Health Science Center at San Antonio · USSouth Texas Veterans Health Care System · US

Funding

PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Ocular blood flow and intraocular pressure homeostasisR01EY009702 · NEI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KIEL, JEFFREY W · 1992 to 2013
$3.3M
Layer-Specific Functional &Perfusion Imaging of RetinaR01EY014211 · NEI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DUONG, TIMOTHY Q. · 2004 to 2011
$3.0M
Layer-specific imaging of retinal degenerationR01EY018855 · NEI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DUONG, TIMOTHY Q. · 2009 to 2012
$769k
NEI NIH HHS R01 EY009702NEI NIH HHS R01 EY014211NEI NIH HHS R01 EY018855NEI NIH HHS R01 EY09702NHLBI NIH HHS T32 HL007446
6 · The paper itself

Abstract

3D-MR microscopy at 11.7T and 20 × 20 × 57 μm resolution was performed on formalin-fixed rat eyes with: (I) no contrast agent and (II) Gadodiamide (Omniscan(®) ) added to the fixative. Group I data showed generally poor contrast among layers. Group II data showed markedly better lamina-specific contrast with the nerve fiber + ganglion cell layer and inner nuclear layer being hypointense, and the inner plexiform, outer plexiform, outer nuclear layer, and the segments being hyperintense. The signal-to-noise ratio in group II was higher than group I, consistent with Gadodiamide acting as a T(1) -contrast agent. All major retinal layers were assigned and their thicknesses quantified with corroboration by histology. MR microscopy allows nondestructive examination of valuable specimens and could have applications in disease and in vivo.

Indexed as

AnimalsContrast MediaGadolinium DTPAImaging, Three-DimensionalIn Vitro TechniquesMagnetic Resonance ImagingRatsRats, Sprague-DawleyRetinaSignal-To-Noise RatioContrast MediagadodiamideGadolinium DTPA

Identifiers

PMID22009721
PMCPMC3262931
OpenAlexW2130157786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.