ArticleNucleic acids research2012
PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Connecting links with code: AI in morphological evolution.Frontiers in bioinformatics · 2026Review
- A3DyDB: exploring structural aggregation propensities in the yeast proteome.Microbial cell factories · 2023Article
- Systematic exploration of cell morphological phenotypes associated with a transcriptomic query.Nucleic acids research · 2018Article
- Systematic analysis of CaMolecular biology of the cell · 2017Article
- Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.Nature chemical biology · 2016Article
- Mutant power: using mutant allele collections for yeast functional genomics.Briefings in functional genomics · 2016Review
- High-throughput bacterial functional genomics in the sequencing era.Current opinion in microbiology · 2015Review
- Module-based construction of plasmids for chromosomal integration of the fission yeast Schizosaccharomyces pombe.Open biology · 2015Article
- CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2015Article
- Predicting complex phenotype-genotype interactions to enable yeast engineering: Saccharomyces cerevisiae as a model organism and a cell factory.Biotechnology journal · 2013Review
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11 authors at 1 institution in 1 country.
Funding
Abstract
About one-fifth of the genes in the budding yeast are essential for haploid viability and cannot be functionally assessed using standard genetic approaches such as gene deletion. To facilitate genetic analysis of essential genes, we and others have assembled collections of yeast strains expressing temperature-sensitive (ts) alleles of essential genes. To explore the phenotypes caused by essential gene mutation we used a panel of genetically engineered fluorescent markers to explore the morphology of cells in the ts strain collection using high-throughput microscopy. Here, we describe the design and implementation of an online database, PhenoM (Phenomics of yeast Mutants), for storing, retrieving, visualizing and data mining the quantitative single-cell measurements extracted from micrographs of the ts mutant cells. PhenoM allows users to rapidly search and retrieve raw images and their quantified morphological data for genes of interest. The database also provides several data-mining tools, including a PhenoBlast module for phenotypic comparison between mutant strains and a Gene Ontology module for functional enrichment analysis of gene sets showing similar morphological alterations. The current PhenoM version 1.0 contains 78,194 morphological images and 1,909,914 cells covering six subcellular compartments or structures for 775 ts alleles spanning 491 essential genes. PhenoM is freely available at http://phenom.ccbr.utoronto.ca/.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.