ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2011
Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 19 citations in OpenAlex.
- Non-homologous sequence interactions during meiosis: meiotic challenges and evolutionary opportunities.Current opinion in genetics & development · 2025Review
- Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells.Cell division · 2020Article
- Achilles' heel of pluripotent stem cells: genetic, genomic and epigenetic variations during prolonged culture.Cellular and molecular life sciences : CMLS · 2016Review
- SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells.Stem cell reports · 2014Article
- c-MYC-induced genomic instability.Cold Spring Harbor perspectives in medicine · 2014Review
- Preclinical studies for induced pluripotent stem cell-based therapeutics.The Journal of biological chemistry · 2014Review
- Embryonic stem cells or induced pluripotent stem cells? A DNA integrity perspective.Current gene therapy · 2013Review
- Fast quantitative real-time PCR-based screening for common chromosomal aneuploidies in mouse embryonic stem cells.Stem cell reports · 2013Article
- Genetic instability of modified stem cells - a first step towards malignant transformation?American journal of stem cells · 2013Article
- A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins.Nature communications · 2013Article
- Recurrent transcriptional clusters in the genome of mouse pluripotent stem cells.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induced pluripotent stem (iPS) cells have greatly provoked people's interest due to their enormous potential of clinical applications. Increasing care is taken with the genetic safety of iPS cells. However, up to now, the chromosomal integrity of murine iPS (miPS) cells has been largely unknown. We have observed recurrent trisomy and/or Robertsonian translocation (Rb) of chromosome 14 in six out of nine independent miPS cell lines from three laboratories by G-banding, fluorescence in situ hybridization (FISH) and spectral karyotyping (SKY) analyses, while all the miPS cell lines were derived from mouse embryonic fibroblasts (MEFs) or neural precursor cells (NPCs) with a normal karyotype. The miPS cells with trisomy and/or Rb of chromosome 14 showed growth advantage over the miPS cells with a normal karyotype. We found a significantly higher frequency of Rbs in the miPS cell lines induced with c-Myc than those without c-Myc. Our findings demonstrate that miPS cell lines have the propensity for chromosomal aberrations and there is an obvious correlation between the extent of chromosomal aberrations in miPS cells and the transcriptional factors used for their reprogramming. Therefore, our study raises awareness of the need for improvements of the induction conditions of miPS cells in order to avoid the chromosomal aberrations and ensure future safe applications.
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