ArticleClinical oral investigations2012
Increased systemic elastase and C-reactive protein in aggressive periodontitis (CLOI-D-00160R2).
Article in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Serum C-Reactive Protein and Periodontitis: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Effect of Subgingival Instrumentation on Neutrophil Elastase and C-Reactive Protein in Grade B and C Periodontitis: Exploratory Analysis of a Prospective Cohort Study.Journal of clinical medicine · 2022Article
- Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia.Periodontology 2000 · 2022Review
- Article
- High Fat Diet Dysbiotic Mechanism of Decreased Gingival Blood Flow.Frontiers in physiology · 2021Article
- Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis.Clinical oral investigations · 2020Article
- Article
- Inflammatory serum markers up to 5 years after comprehensive periodontal therapy of aggressive and chronic periodontitis.Clinical oral investigations · 2018Article
- C-reactive protein in patients with aggressive periodontitis.Journal of dental sciences · 2017Article
- Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis.Clinical oral investigations · 2017Article
- Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis.Frontiers in microbiology · 2017Article
- C-Reactive Protein in Peripheral Blood of Patients with Chronic and Aggressive Periodontitis, Gingivitis, and Gingival Recessions.Mediators of inflammation · 2015Article
- Comparative evaluation of serum C-reactive protein levels in chronic and aggressive periodontitis patients and association with periodontal disease severity.Contemporary clinical dentistry · 2014Article
- Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.Inflammation · 2014Article
- Clinical results after nonsurgical therapy in aggressive and chronic periodontitis.Clinical oral investigations · 2014Article
- C - reactive protein levels in patients with periodontal disease and normal subjects.International journal of molecular and cellular medicine · 2013Article
- [Physiology of the oral cavity. Dermatologic aspects].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inflammatory mediators, serum elastase and C-reactive protein (CRP), are associated with an increased risk for coronary heart disease. Thus, the aim of this study is to compare systemic inflammatory mediators in periodontally healthy controls (C), patients with untreated aggressive (AgP) and chronic (ChP) periodontitis. C [periodontal pocket probing depth (PPD) <3.6 or <5 mm without bleeding (BOP), BOP < 10%], ChP (PDD ≥ 3.6 mm and probing attachment loss ≥5 mm at >30% of sites; age >35 years), and AgP (clinically healthy; PDD ≥ 3.6 mm at >30% of sites, bone loss ≥50% at ≥2 teeth; age ≤35 years) were examined clinically, and the body mass index was assessed. Blood was sampled for assessment of serum levels of elastase, CRP, lipopolysaccharide binding protein (LBP), interleukin (IL) 6, 8, and leukocyte counts. Thirty C, 31 ChP, and 29 AgP were analyzed. Elastase, CRP, LBP, and IL-6 levels were elevated in AgP compared to C (p < 0.013), whereas leukocyte counts and IL-8 were similar. Multiple regression analysis identified AgP (p < 0.001) and education level (p < 0.001) to explain 47% of the variation of elastase. AgP (p = 0.003), African origin (p = 0.006), female sex (p = 0.002), and BMI (p < 0.001) explained 39% of the variation of CRP. Serum elastase and CRP are significantly elevated in AgP compared to C. AgP patients exhibit a stronger systemic inflammatory burden than C patients.
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