ArticleCancer2012
Insulin resistance, central obesity, and risk of colorectal adenomas.
Article in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Trial
- Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort.World journal of surgical oncology · 2026Article
- Integrated Metabolic and Inflammatory Clustering Reveals Distinct Risk Profiles for Digestive Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Association between dietary fructose and human colon DNA methylation: implication for racial disparities in colorectal cancer risk using a cross-sectional study.The American journal of clinical nutrition · 2025Article
- Correlation Between Skeletal Muscle Mass and Different Pathological Types of Colorectal Polyp in Chinese Asymptomatic Population.International journal of general medicine · 2025Article
- Article
- Obesity-Associated Colorectal Cancer.International journal of molecular sciences · 2024Review
- The Association of Metabolic Risk Factors with Advanced Adenomas in Hispanic Patients.Digestive diseases and sciences · 2024Article
- Dietary inflammatory index and risk of colorectal adenoma: effect measure modification by race, nonsteroidal anti-inflammatory drugs, cigarette smoking and body mass index?Cancer causes & control : CCC · 2021Article
- Young Adult Cancer: Influence of the Obesity Pandemic.Obesity (Silver Spring, Md.) · 2018Review
- Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies.Yonsei medical journal · 2017Article
- What Can We Learn from Interventions That Change Fat Distribution?Current obesity reports · 2016Review
- Associations Between Parameters of Glucose and Lipid Metabolism and Risk of Colorectal Neoplasm.Digestive diseases and sciences · 2015Article
- Serum levels of retinol-binding protein 4 and risk of colon adenoma.Endocrine-related cancer · 2015Article
- Impact of high glucose on metastasis of colon cancer cells.World journal of gastroenterology · 2015Article
- Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans.Journal of diabetes investigation · 2014Article
- Racial differences in the association of insulin-like growth factor pathway and colorectal adenoma risk.Cancer causes & control : CCC · 2014Article
- Metabolic syndrome is associated with increased prevalence of advanced colorectal polyps.The journal of nutrition, health & aging · 2014Article
- Type 2 diabetes and the risk of colorectal adenomas: Black Women's Health Study.American journal of epidemiology · 2014Article
- Adipokines do not mediate the association of obesity and colorectal adenoma.Journal of cancer epidemiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIncreasing evidence supports insulin resistance (IR) as the underpinning of the obesity-colorectal neoplasia link. The homeostasis model assessment-IR (HOMA-IR) is a widely accepted index of evolving hyperinsulinemia and early IR. Studies of the relation between HOMA-IR and colorectal adenomas are limited. Therefore, the authors sought to determine the associations of HOMA-IR and central obesity (waist to hip ratio [WHR]) with risk of colorectal adenomas in a screening colonoscopy-based study.
methodsThe authors collected lifestyle information and fasting blood samples from 1222 participants (320 incident adenoma cases and 902 without adenomas) before their screening colonoscopies. Unconditional logistic regression models were used to assess risk associations.
resultsIn multivariate analysis of participants (n = 1093) reporting no antidiabetic medication use, those in the top quartile of WHR were twice as likely (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.33-3.57; P-trend = .003) and those in the top quartile of HOMA-IR were 63% more likely (OR, 1.63; 95% CI, 1.09-2.44; P-trend = .01) to have adenomas compared with those in the bottom quartiles. Stratified analysis revealed a statistically significant interaction between HOMA-IR and sex (P-interaction = .04), with the association largely limited to men; compared with those in the bottom tertile, men in the top tertile of HOMA-IR were twice more likely to have adenomas (OR, 2.11; 95% CI, 1.18-3.78; P-trend = .01).
conclusionsThe results support central obesity and insulin resistance, particularly in men, as important risk factors for the development of early colorectal neoplasia.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.