ArticleTropical animal health and production2012
Polymorphisms in the bovine HSP90AB1 gene are associated with heat tolerance in Thai indigenous cattle.
Article in Tropical animal health and production, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 89 citations in OpenAlex.
- Physiochemical and transcriptomics of exotic holstein friesian cattle in Pakistani subtropics.Tropical animal health and production · 2025Article
- Genetic variation in the bovine heat shock protein gene in Indonesian Bali cattle (Open veterinary journal · 2025Article
- Article
- Association analysis of HSP90AA1 polymorphism with thermotolerance in tropically adapted Indian crossbred cattle.Tropical animal health and production · 2024Article
- Potentials of single nucleotide polymorphisms and genetic diversity studies at HSP90AB1 gene in Nigerian White Fulani, Muturu, and N'Dama cattle breeds.Tropical animal health and production · 2024Article
- Association of heat-shock protein 70.1 gene with physiological and physical performance of Bali cattle.Veterinary world · 2024Article
- Genomic regions and biological mechanisms underlying climatic resilience traits derived from automatically-recorded vaginal temperature in lactating sows under heat stress conditions.Frontiers in genetics · 2024Article
- Comprehensive selection signature analyses in dairy cattle exploiting purebred and crossbred genomic data.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Analysis of Potential Genes and Economic Parameters Associated with Growth and Heat Tolerance in Sheep (Animals : an open access journal from MDPI · 2023Article
- Association of selected gene polymorphisms with thermotolerance traits in cattle - A review.Animal bioscience · 2022Article
- Genetic diversity and signatures of selection for heat tolerance and immune response in Iranian native chickens.BMC genomics · 2022Article
- Selection Signatures in South African Nguni and Bonsmara Cattle Populations Reveal Genes Relating to Environmental Adaptation.Frontiers in genetics · 2022Article
- Comparative miRNA signatures among Sahiwal and Frieswal cattle breeds during summer stress.3 Biotech · 2021Article
- Heterozygous Single-Nucleotide Polymorphism Genotypes at Heat Shock Protein 70 Gene Potentially Influence Thermo-Tolerance Among Four Zebu Breeds of Nigeria.Frontiers in genetics · 2021Article
- A novel T177P missense variant in the HSPA8 gene associated with the low tolerance of Awassi sheep to heat stress.Tropical animal health and production · 2020Article
- Single nucleotide polymorphisms at heat shock protein 90 gene and their association with thermo-tolerance potential in selected indigenous Nigerian cattle.Tropical animal health and production · 2020Article
- Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach.BMC genetics · 2019Article
- Growth performance of Lowline Angus x Thai native crossbred beef under tropical condition.Tropical animal health and production · 2019Article
- Size does matter: Parallel evolution of adaptive thermal tolerance and body size facilitates adaptation to climate change in domestic cattle.Ecology and evolution · 2018Article
- Identification of differentially expressed microRNAs in Sahiwal (Bos indicus) breed of cattle during thermal stress.Cell stress & chaperones · 2018Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock proteins act as molecular chaperones that have preferentially been transcribed in response to severe perturbations of the cellular homeostasis such as heat stress. Here the traits respiration rate (RR), rectal temperature (RT), pack cell volume (PCV) and the individual heat tolerance coefficient (HTC) were recorded as physiological responses on heat stress (environmental temperatures) in Bos taurus (crossbred Holstein Friesian; HF) and B. indicus (Thai native cattle: White Lamphun; WL and Mountain cattle; MT) animals (n = 47) in Thailand. Polymorphisms of the heat shock protein 90-kDa beta gene (HSP90AB1) were evaluated by comparative sequencing. Nine single nucleotide polymorphisms (SNP) were identified, i.e. three in exons 10 and 11, five in introns 8, 9, 10 and 11, and one in the 3'UTR. The exon 11 SNP g.5082C>T led to a missense mutation (alanine to valine). During the period of extreme heat (in the afternoon) RR and RT were elevated in each of the three breeds, whereas the PCV decreased. Mountain cattle and White Lamphun heifers recorded significantly better physiologic parameters (p < 0.05) in all traits considered, including or particularly HTC than Holstein Friesian heifers. The association analysis revealed that the T allele at SNP g.4338T>C within intron 3 improved the heat tolerance (p < 0.05). Allele T was exclusively found in White Lamphun animals and to 84% in Mountain cattle. Holstein Friesian heifers revealed an allele frequency of only 18%. Polymorphisms within HSP90AB1 were not causative for the physiological responses; however, we propose that they should at least be used as genetic markers to select appropriate breeds for hot climates.
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