ArticleBiological psychology2012
Neural recruitment during failed motor inhibition differentiates youths with bipolar disorder and severe mood dysregulation.
Article in Biological psychology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications.Neuroscience and biobehavioral reviews · 2023Pooled it
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature.European child & adolescent psychiatry · 2023Pooled it
- Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review.Frontiers in psychiatry · 2021Pooled it
- The Status of Irritability in Psychiatry: A Conceptual and Quantitative Review.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Pooled it
- Inhibition-related connectivity predicts irritability risk and resilience across early adolescence.Social cognitive and affective neuroscience · 2026Article
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neural mechanisms of inhibitory control in preadolescent irritability: Insights from the ABCD study.Biological psychology · 2024Article
- Executive function in children with disruptive mood dysregulation disorder compared to attention-deficit/hyperactivity disorder and oppositional defiant disorder, and in children with different irritability levels.European child & adolescent psychiatry · 2024Article
- Deficits in sustained attention in adolescents with bipolar disorder during their first manic episode.Journal of affective disorders · 2023Article
- Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses.Journal of child psychology and psychiatry, and allied disciplines · 2022Review
- Investigating the associations between irritability and hot and cool executive functioning in those with ADHD.BMC psychiatry · 2022Article
- Underlying mechanisms of disruptive mood dysregulation disorder in children: A systematic review by means of research domain criteria.JCPP advances · 2022Review
- Missing the forest for the trees? A high rate of motor and language impairments in Disruptive Mood Dysregulation Disorder in a chart review of inpatient adolescents.European child & adolescent psychiatry · 2021Article
- Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability.Human brain mapping · 2021Article
- White Matter Microstructure in Pediatric Bipolar Disorder and Disruptive Mood Dysregulation Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Neural and behavioral correlates of inhibitory control in youths with varying levels of irritability.Journal of affective disorders · 2020Article
- Accelerated cortical thinning within structural brain networks is associated with irritability in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Temporally sensitive neural measures of inhibition in preschool children across a spectrum of irritability.Developmental psychobiology · 2019Article
- Decreased anterior cingulate activation in a motor task in youths with bipolar disorder.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Controversy exists about whether non-episodic irritability (operationalized as severe mood dysregulation, SMD) should be considered a developmental presentation of pediatric bipolar disorder (BD). While assessments of brain function may address this controversy, only one fMRI study has compared BD versus SMD. We compared neural activation in BD, SMD, and controls during a motor inhibition task, since motor disinhibition is an important clinical feature in both BD and SMD. During failed inhibition, BD youths exhibited less activation in the right anterior cingulate cortex (ACC) and right nucleus accumbens relative to both SMD and healthy youths. Exploratory analyses indicate that, in BD youths, reduced activation in the right ACC may be independent of comorbid ADHD. These findings highlight neural distinctions between the phenotypically related BD and SMD populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.