Evidence map›Paper›PMID 22008211›Full record

ArticleBehavioral and brain functions : BBF2011

Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating.

Peg Nopoulos, Eric A Epping, Tom Wassink, Bradley L Schlaggar, Joel Perlmutter

Open access · goldAbstract read
In one paragraph

Article in Behavioral and brain functions : BBF, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Peg NopoulosDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. peggy-nopoulos@uiowa.edu
Eric A Epping
Tom Wassink
Bradley L Schlaggar
Joel Perlmutter
University of Iowa · USWashington University in St. Louis · US

Funding

Growth and Development of the Striatum in Huntington's DiseaseR01NS055903 · NINDS · UNIVERSITY OF IOWA · PI PEGGY C NOPOULOS · 2009 to 2026
$5.0M
NINDS NIH HHS 5R01NS055903-03NINDS NIH HHS R01 NS055903
6 · The paper itself

Abstract

Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.

Indexed as

Models, GeneticTrinucleotide RepeatsAdolescentAllelesCase-Control StudiesChildFemaleGene DosageGenetic VariationHumansHuntingtin ProteinHuntington DiseaseMaleNerve Tissue ProteinsNuclear ProteinsReference ValuesHTT protein, humanHuntingtin ProteinNerve Tissue ProteinsNuclear Proteins

Identifiers

PMID22008211
PMCPMC3219594
OpenAlexW2106873336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.