Trial reportClinical and experimental hypertension (New York, N.Y. : 1993)2012
Serum aldosterone is associated with inflammation and aortic stiffness in normotensive overweight and obese young adults.
Trial report in Clinical and experimental hypertension (New York, N.Y. : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00366990 (Clinical Trial to Reverse Early Arterial Stiffening), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Trial to Reverse Early Arterial Stiffening
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2013Trial
- Reductions in arterial stiffness with weight loss in overweight and obese young adults: potential mechanisms.Atherosclerosis · 2012Trial
- Discovery of Personalized Treatment for Immuno-Metabolic Depression-Focus on 11beta Hydroxysteroid Dehydrogenase Type 2 (11betaHSD2) and Toll-like Receptor 4 (TLR4) Inhibition with Enoxolone.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Non-Hypertensive Effects of Aldosterone.International journal of molecular sciences · 2025Review
- Treatment withNutrients · 2024Article
- Brain ventricle and choroid plexus morphology as predictor of treatment response in major depression: Findings from the EMBARC study.Brain, behavior, & immunity - health · 2024Article
- Brain Ventricle and Choroid Plexus Morphology as Predictor of Treatment Response: Findings from the EMBARC Study.Research square · 2023Article
- Dissociation of pulse wave velocity and aortic wall stiffness in diabetic db/db mice: The influence of blood pressure.Frontiers in physiology · 2023Article
- New progress on the study of aortic stiffness in age-related hypertension.Journal of hypertension · 2020Review
- Obesity and cardiovascular disease in women.International journal of obesity (2005) · 2020Review
- Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension.Journal of the American Society of Hypertension : JASH · 2018Article
- PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights.BMC cardiovascular disorders · 2017Article
- Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet.Frontiers in physiology · 2017Article
- Repeatability of Central and Peripheral Pulse Wave Velocity Measures: The Atherosclerosis Risk in Communities (ARIC) Study.American journal of hypertension · 2016Article
- Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet-Induced Arterial Stiffening in Female Mice.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis.Frontiers in endocrinology · 2015Review
- Aldosterone and vascular mineralocorticoid receptors: regulators of ion channels beyond the kidney.Hypertension (Dallas, Tex. : 1979) · 2014Review
- Smooth muscle cell mineralocorticoid receptors are mandatory for aldosterone-salt to induce vascular stiffness.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Regional pulse wave velocities and their cardiovascular risk factors among healthy middle-aged men: a cross-sectional population-based study.BMC cardiovascular disorders · 2014Article
- Associations between arterial stiffness and platelet activation in normotensive overweight and obese young adults.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Circulating aldosterone is increased in obesity and is associated with arterial stiffening in hypertensives and older adults. The aim of this article was to determine whether serum aldosterone is associated with pulse wave velocity (PWV), a measure of arterial stiffness, in normotensive overweight and obese adults aged 20-45 years (n = 344). Heart-femoral, femoral-ankle, and brachial-ankle PWV were measured. The sample was 77% female with mean body mass index 32.9 kg/m(2) (SD 3.9), median serum aldosterone 106.5 pg/mL (interquartile range 79.9, 155.5), and mean 24-hour urinary sodium excretion 185.9 mEq/day (SD 69.6). Higher serum aldosterone was not significantly correlated with any PWV measure in bivariate analysis. However, in multiple linear regression, adjusting for age, sex, race, height, heart rate, mean arterial pressure, and waist circumference, higher log aldosterone was associated with greater log heart-femoral PWV (β(se) = 0.042(0.021), P = .049). After adjusting for C-reactive protein, this association was no longer significant (β(se) = 0.035(0.021), P = .10). Circulating aldosterone may play an important role in vascular inflammation and aortic stiffening in normotensive overweight and obese adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.