ArticleInternational journal of hepatology2012
Aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis.
Article in International journal of hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts.Epigenomics · 2018Pooled it
- Epigenetics of Trauma Transmission and Fetal Alcohol Spectrum Disorder: What Does the Evidence Support?International journal of environmental research and public health · 2023Review
- An Interplay between Epigenetics and Translation in Oocyte Maturation and Embryo Development: Assisted Reproduction Perspective.Biomedicines · 2022Review
- Article
- Integrated analysis of the gene expression profile and DNA methylation profile of obese patients with type 2 diabetes.Molecular medicine reports · 2018Article
- Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.Epigenetics · 2015Review
- New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases.World journal of gastroenterology · 2014Review
- New insights on the role of epigenetic alterations in hepatocellular carcinoma.Journal of hepatocellular carcinoma · 2014Review
- Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets.BioMed research international · 2014Review
- Zebrafish models of human liver development and disease.Comprehensive Physiology · 2013Review
- Folate, alcohol, and liver disease.Molecular nutrition & food research · 2013Review
- In utero alcohol exposure, epigenetic changes, and their consequences.Alcohol research : current reviews · 2013Review
- Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes.Hepatology (Baltimore, Md.) · 2012Article
- Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.Advances in experimental medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The pathogenesis of alcoholic steatohepatitis (ASH) involves ethanol-induced aberrations in hepatic methionine metabolism that decrease levels of S-adenosylmethionine (SAM), a compound which regulates the synthesis of the antioxidant glutathione and is the principal methyl donor in the epigenetic regulation of genes relevant to liver injury. The present paper describes the effects of ethanol on the hepatic methionine cycle, followed by evidence for the central role of reduced SAM in the pathogenesis of ASH according to clinical data and experiments in ethanol-fed animals and in cell models. The efficacy of supplemental SAM in the prevention of ASH in animal models and in the clinical treatment of ASH will be discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.