ArticleJournal of parasitology research2012
The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection.
Article in Journal of parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Trends and Gaps in the Scientific Literature about the Effects of Nutritional Supplements on Canine Leishmaniosis.Pathogens (Basel, Switzerland) · 2024Pooled it
- Vitamin D status, vitamin D receptor gene polymorphism, and haplotype in patients with cutaneous leishmaniasis: Correlation with susceptibility and parasite load index.PLoS neglected tropical diseases · 2023Article
- Vitamins A and D and Zinc Affect the Leshmanicidal Activity of Canine Spleen Leukocytes.Animals : an open access journal from MDPI · 2021Article
- Vitamin d and leishmaniasis: Neither seasonal nor risk factor in canine host but potential adjuvant treatment through cbd103 expression.PLoS neglected tropical diseases · 2021Article
- Vitamin D increases killing of intracellularParasitology · 2020Article
- Micronutrient levels and their effects on the prognosis of visceral leishmaniasis treatment, a prospective cohort study.BMC infectious diseases · 2020Article
- Serum 25-hydroxyvitamin D level and vitamin D receptor (VDR) polymorphisms in patients infected withJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Vitamins (A&D) and Isoprenoid (Chenodeoxycholic acid) molecules are accompanied by Th1 immunostimulatory response and therapeutic cure in vivo: possible antileishmanial drugs.Scientific reports · 2019Article
- Macrophage nuclear receptors: Emerging key players in infectious diseases.PLoS pathogens · 2019Review
- Dietary Vitamin D3 Deficiency Increases Resistance toFrontiers in cellular and infection microbiology · 2019Article
- Impact of Childhood Malnutrition on Host Defense and Infection.Clinical microbiology reviews · 2017Review
- Cutaneous Manifestations of Human and Murine Leishmaniasis.International journal of molecular sciences · 2017Review
- Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency.Scientific reports · 2017Article
- Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy.Scientific reports · 2016Article
- Vitamin D every day to keep the infection away?Nutrients · 2015Review
- Post kala-azar dermal leishmaniasis: an unresolved mystery.Trends in parasitology · 2014Review
- Vitamin D and inflammatory diseases.Journal of inflammation research · 2014Review
- A transcriptomic network identified in uninfected macrophages responding to inflammation controls intracellular pathogen survival.Cell host & microbe · 2013Article
- Article
- Higher Serum Vitamin D Levels have a Positive Association with the Incidence of Recidivans Form of Cutaneous Leishmaniasis; A Cross-Sectional Study.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Vitamin D signaling modulates a variety of immune responses. Here, we assessed the role of vitamin D in immunity to experimental leishmaniasis infection in vitamin D receptor-deficient mice (VDRKO). We observed that VDRKO mice on a genetically resistant background have decreased Leishmania major-induced lesion development compared to wild-type (WT) mice; additionally, parasite loads in infected dermis were significantly lower at the height of infection. Enzymatic depletion of the active form of vitamin D mimics the ablation of VDR resulting in an increased resistance to L. major. Conversely, VDRKO or vitamin D-deficient mice on the susceptible Th2-biased background had no change in susceptibility. These studies indicate vitamin D deficiency, either through the ablation of VDR or elimination of its ligand, 1,25D3, leads to an increase resistance to L. major infection but only in a host that is predisposed for Th-1 immune responses.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.