ReviewClinical & developmental immunology2011
Asbestos induces reduction of tumor immunity.
Review in Clinical & developmental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes.Environmental health and preventive medicine · 2020Review
- The Effects of Asbestos Fibers on Human T Cells.International journal of molecular sciences · 2020Review
- Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos.Environmental health and preventive medicine · 2017Review
- Accelerated cell cycle progression of human regulatory T cell-like cell line caused by continuous exposure to asbestos fibers.International journal of oncology · 2017Article
- Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment.Environmental health and preventive medicine · 2016Review
- CTLA4 blockade in mesothelioma: finally a competing strategy over cytotoxic/target therapy?Cancer immunology, immunotherapy : CII · 2015Review
- Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice.Toxicology and applied pharmacology · 2014Article
- Autoimmunity and asbestos exposure.Autoimmune diseases · 2014Review
- Changes in global gene expression associated with 3D structure of tumors: an ex vivo matrix-free mesothelioma spheroid model.PloS one · 2012Article
- Tumor-induced CD8+ T-cell dysfunction in lung cancer patients.Clinical & developmental immunology · 2012Review
- Amphibole, but not chrysotile, asbestos induces anti-nuclear autoantibodies and IL-17 in C57BL/6 mice.Journal of immunotoxicologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asbestos-related cancers such as malignant mesothelioma and lung cancer are an important issue in the world. There are many conflicts concerning economical considerations and medical evidence for these cancers and much confusion regarding details of the pathological mechanisms of asbestos-induced cancers. For example, there is uncertainty concerning the degree of danger of the iron-absent chrysotile compared with iron-containing crocidolite and amosite. However, regarding bad prognosis of mesothelioma, medical approaches to ensure the recognition of the biological effects of asbestos and the pathological mechanisms of asbestos-induced carcinogenesis, as well as clinical trials to detect the early stage of mesothelioma, should result in better preventions and the cure of these malignancies. We have been investigating the immunological effects of asbestos in relation to the reduction of tumor immunity. In this paper, cellular and molecular approaches to clarify the immunological effects of asbestos are described, and all the findings indicate that the reduction of tumor immunity is caused by asbestos exposure and involvement in asbestos-induced cancers. These investigations may not only allow the clear recognition of the biological effects of asbestos, but also present a novel procedure for early detection of previous asbestos exposure and the presence of mesothelioma as well as the chemoprevention of asbestos-related cancers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.