ArticleFrontiers in synaptic neuroscience2011
A history of spike-timing-dependent plasticity.
Article in Frontiers in synaptic neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers, 1 of them a synthesis that pooled it.
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Who cites it
168 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of brain-computer interface controlled functional electrical stimulation training on rehabilitation of upper limb after stroke: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Brain and spinal cord paired stimulation coupled with locomotor training affects polysynaptic flexion reflex circuits in human spinal cord injury.Experimental brain research · 2022Trial
- Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke.Nature communications · 2018Trial
- Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans.Science translational medicine · 2018Trial
- RIFT: A Fractal-Holographic Theory of Consciousness and Autopoietic Control.Brain sciences · 2026Article
- Synaptic-state-dependent plasticity routes learning signals in recurrent circuits.bioRxiv : the preprint server for biology · 2026Article
- Irregular and bursty neuronal firing extend spike-timing dependent plasticity window to behavioral timescales.iScience · 2026Article
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.Research square · 2026Article
- Article
- Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks.bioRxiv : the preprint server for biology · 2026Article
- Intrinsic stabilization of synaptic plasticity improves learning and robustness in artificial neural networks.Nature communications · 2026Article
- Bio-Inspired Spike-Timing-Dependent Plasticity Learning with Metal Halide Perovskites: Toward Artificial Synaptic Functionality.ACS applied materials & interfaces · 2026Article
- A proposal for realizing cognitive functions using traveling waves, phase-locked and synchronized patterns, holography, neural mixing, and single sideband communications.Frontiers in computational neuroscience · 2026Article
- Disentangling the Functional Roles of Premotor-Motor Pathways in Automatic Imitation: A Combined Network-Based Transcranial Stimulation and Drift Diffusion Modeling Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Plateau potentials are instructive signals for behavioral timescale synaptic plasticity in the neocortex.bioRxiv : the preprint server for biology · 2025Article
- Genetic Mechanisms of Experience-Dependent Neuronal Plasticity.Annual review of genetics · 2025Review
- Impaired Synaptic Plasticity Mediated by Decreased GLUT1 in Hippocampal Astrocytes is Involved in Postoperative Cognitive Dysfunction in Elderly Mice.Molecular neurobiology · 2025Article
- Enhancing Human Action Inhibition Through Cortico-Cortical Paired Associative Stimulation.Annals of the New York Academy of Sciences · 2025Article
- Promoting motor recovery after stroke using cortico-cortical paired associative stimulation.EClinicalMedicine · 2025Review
- Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
108 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
How learning and memory is achieved in the brain is a central question in neuroscience. Key to today's research into information storage in the brain is the concept of synaptic plasticity, a notion that has been heavily influenced by Hebb's (1949) postulate. Hebb conjectured that repeatedly and persistently co-active cells should increase connective strength among populations of interconnected neurons as a means of storing a memory trace, also known as an engram. Hebb certainly was not the first to make such a conjecture, as we show in this history. Nevertheless, literally thousands of studies into the classical frequency-dependent paradigm of cellular learning rules were directly inspired by the Hebbian postulate. But in more recent years, a novel concept in cellular learning has emerged, where temporal order instead of frequency is emphasized. This new learning paradigm - known as spike-timing-dependent plasticity (STDP) - has rapidly gained tremendous interest, perhaps because of its combination of elegant simplicity, biological plausibility, and computational power. But what are the roots of today's STDP concept? Here, we discuss several centuries of diverse thinking, beginning with philosophers such as Aristotle, Locke, and Ribot, traversing, e.g., Lugaro's plasticità and Rosenblatt's perceptron, and culminating with the discovery of STDP. We highlight interactions between theoretical and experimental fields, showing how discoveries sometimes occurred in parallel, seemingly without much knowledge of the other field, and sometimes via concrete back-and-forth communication. We point out where the future directions may lie, which includes interneuron STDP, the functional impact of STDP, its mechanisms and its neuromodulatory regulation, and the linking of STDP to the developmental formation and continuous plasticity of neuronal networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.