ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2011
In vivo Cerenkov luminescence imaging: a new tool for molecular imaging.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 160 citations in OpenAlex.
- Current Status of Cherenkov-Based Gamma Detectors for TOF-PET and Proton Range Verification.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Nanoradiopharmaceuticals: Design Principles, Radiolabeling Strategies, and Biomedicine Applications.Pharmaceutics · 2025Review
- Optical (Cherenkov) dosimetry to unravel the radiobiological effects of radioisotope based therapy.European journal of nuclear medicine and molecular imaging · 2025Article
- Hybrid Monte Carlo model for efficient tissue Cherenkov emission estimation to assess changes from beam size, energy and incidence.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025Article
- Exploring innovative strides in radiolabeled nanoparticle progress for multimodality cancer imaging and theranostic applications.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- Amplification of Cerenkov luminescence using semiconducting polymers for cancer theranostics.Advanced functional materials · 2023Article
- Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts.Cancer nanotechnology · 2023Review
- Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- In vivo molecular imaging in preclinical research.Laboratory animal research · 2022Review
- In situ lymphoma imaging in a spontaneous mouse model using the Cerenkov Luminescence of F-18 and Ga-67 isotopes.Scientific reports · 2021Article
- Prostate specific membrane antigen-radio guided surgery using Cerenkov luminescence imaging-utilization of a short-pass filter to reduce technical pitfalls.Translational andrology and urology · 2021Article
- Radiopharmaceutical and EuJournal of nanobiotechnology · 2021Article
- Intraperitoneal Glucose Transport to Micrometastasis: A Multimodal In Vivo Imaging Investigation in a Mouse Lymphoma Model.International journal of molecular sciences · 2021Article
- Surgical Advances in Osteosarcoma.Cancers · 2021Review
- A review of recent and emerging approaches for the clinical application of Cerenkov luminescence imaging.Frontiers in physics · 2021Article
- Cerenkov Luminescence Imaging in the Development and Production of Radiopharmaceuticals.Frontiers in physics · 2021Article
- Fluorescence Emission Triggered by RadioactivePhysical review applied · 2020Article
- Cerenkov luminescence and PET imaging ofPhysics in medicine and biology · 2020Article
- Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors.Frontiers in immunology · 2020Review
- Performance evaluation of Cerenkov luminescence imaging: a comparison ofEJNMMI physics · 2019Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cerenkov radiation is a phenomenon where optical photons are emitted when a charged particle moves faster than the speed of light for the medium in which it travels. Recently, we and others have discovered that measurable visible light due to the Cerenkov effect is produced in vivo following the administration of β-emitting radionuclides to small animals. Furthermore, the amounts of injected activity required to produce a detectable signal are consistent with small-animal molecular imaging applications. This surprising observation has led to the development of a new hybrid molecular imaging modality known as Cerenkov luminescence imaging (CLI), which allows the spatial distribution of biomolecules labelled with β-emitting radionuclides to be imaged in vivo using sensitive charge-coupled device cameras. We review the physics of Cerenkov radiation as it relates to molecular imaging, present simulation results for light intensity and spatial distribution, and show an example of CLI in a mouse cancer model. CLI allows many common radiotracers to be imaged in widely available in vivo optical imaging systems, and, more importantly, provides a pathway for directly imaging β(-)-emitting radionuclides that are being developed for therapeutic applications in cancer and that are not readily imaged by existing methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.