ReviewPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2011
Haemoglobin oxygen saturation as a biomarker: the problem and a solution.
Review in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed.
- Monitoring cerebral oxygenation during balloon occlusion with multichannel NIRS.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- In vivo multiphoton NADH fluorescence reveals depth-dependent keratinocyte metabolism in human skin.Biophysical journal · 2013Trial
- Ultrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressure.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hybrid three-dimensional full-view multi-wavelength photoacoustic and ultrasound breast tomography.Photoacoustics · 2026Article
- Neonatal cerebral hemodynamics under elevated intracranial pressure: a near-infrared spectroscopy study in piglets.Pediatric research · 2026Article
- MW-FlexNIRS: wearable, low-cost, LED-based, multi-wavelength NIRS oximeter for cytochrome c oxidase recovery in neonates.Biomedical optics express · 2026Article
- Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats.Journal of biomedical optics · 2026Article
- Associations between postnatal cerebral oxygen availability and utilization in very to late preterm infants and neurodevelopmental outcome.Scientific reports · 2026Observational
- State-of-the-art wearable sensors for cardiovascular health: a review.NPJ cardiovascular health · 2025Review
- Fast Multi-Distance Time-Domain NIRS and DCS System for Clinical Applications.Sensors (Basel, Switzerland) · 2024Article
- Initiatives to improve lung and sleep health in children: Delphi consensus from the pediatrics, pulmonary, and sleep conference.Pediatric pulmonology · 2024Article
- Understanding metabolic responses to forearm arterial occlusion measured with two-channel broadband near-infrared spectroscopy.Journal of biomedical optics · 2024Article
- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.Nature communications · 2024Article
- Noninvasive Temperature Measurements in Tissue-Simulating Phantoms Using a Solid-State Near-Infrared Sensor.Sensors (Basel, Switzerland) · 2024Article
- HyperTRCSS: A hyperspectral time-resolved compressive sensing spectrometer for depth-sensitive monitoring of cytochrome-c-oxidase and blood oxygenation.Journal of biomedical optics · 2024Article
- Measuring and imaging of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy.Journal of biomedical optics · 2023Article
- Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy.Brain sciences · 2023Article
- A flexible optoacoustic blood 'stethoscope' for noninvasive multiparametric cardiovascular monitoring.Nature communications · 2023Article
- Enhancing diffuse correlation spectroscopy pulsatile cerebral blood flow signal with near-infrared spectroscopy photoplethysmography.Neurophotonics · 2023Article
- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.bioRxiv : the preprint server for biology · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Near-infrared spectroscopy measures of haemoglobin oxygen saturation are often used as an indicator of sufficient oxygen delivery to assess injury susceptibility and tissue damage. They have also often been used as a surrogate measure of oxygen metabolism. Unfortunately, these measures have generally failed to provide robust indicators of injury and metabolism. In this paper, we first review when haemoglobin oxygen saturation does work as a robust indicator, and then detail when and why it fails for assessing brain injury and breast cancer. Finally, we discuss the solution to obtain more robust measures of tissue injury and cancer by combining oxygen saturation measurements with measures of blood flow and volume to more accurately estimate oxygen metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.