ArticleNucleic acids research2012
Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 74 citations in OpenAlex.
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- An MKT1 domain protein is dispensable for erythrocytic stages ofFrontiers in microbiology · 2026Article
- Ectopic overexpression ofMicrobiology spectrum · 2025Article
- Evolution of sequence, structural and functional diversity of the ubiquitous DNA/RNA-binding Alba domain.Scientific reports · 2024Article
- Article
- Proteome-Wide Identification of RNA-dependent proteins and an emerging role for RNAs in Plasmodium falciparum protein complexes.Nature communications · 2024Article
- Discovery of RUF6 ncRNA-interacting proteins involved inLife science alliance · 2023Article
- The Putative Bromodomain Protein PfBDP7 of the Human Malaria ParasiteFrontiers in cell and developmental biology · 2022Article
- The RNA structurome in the asexual blood stages of malaria pathogenRNA biology · 2021Article
- Genome-wide identification and expression profiling of Alba gene family members in response to abiotic stress in tomato (Solanum lycopersicum L.).BMC plant biology · 2021Article
- Phage Display Screening for Alba Superfamily Proteins from the Human Malaria Parasite, Plasmodium falciparum Reveals a High Level of Association with Protein Modification Pathways and Hints at New Drug Targets.Acta parasitologica · 2021Article
- An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition.PLoS pathogens · 2021Article
- Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite.Molecular systems biology · 2020Article
- PfSWIB, a potential chromatin regulator for var gene regulation and parasite development in Plasmodium falciparum.Parasites & vectors · 2020Article
- Unraveling the 3D genome of human malaria parasites.Seminars in cell & developmental biology · 2019Review
- Knockdown ofFrontiers in plant science · 2019Article
- Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasiteeLife · 2018Article
- Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development.Nature communications · 2018Article
- Article
- Parasite-Related Genetic and Epigenetic Aspects and Host Factors InfluencingFrontiers in cellular and infection microbiology · 2018Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the DNA-binding nature as well as the function of a putative Alba (Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum. PfAlba3 possesses DNA-binding property like Alba family proteins. PfAlba3 binds to DNA sequence non-specifically at the minor groove and acetylation lowers its DNA-binding affinity. The protein is ubiquitously expressed in all the erythrocytic stages of P. falciparum and it exists predominantly in the acetylated form. PfAlba3 inhibits transcription in vitro by binding to DNA. Plasmodium falciparum Sir2 (PfSir2A), a nuclear localized deacetylase interacts with PfAlba3 and deacetylates the lysine residue of N-terminal peptide of PfAlba3 specific for DNA binding. PfAlba3 is localized with PfSir2A in the periphery of the nucleus. Fluorescence in situ hybridization studies revealed the presence of PfAlba3 in the telomeric and subtelomeric regions. ChIP and ChIP ReChIP analyses further confirmed that PfAlba3 binds to the telomeric and subtelomeric regions as well as to var gene promoter.
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