ArticleGenetic epidemiology2011
Identity-by-descent-based phasing and imputation in founder populations using graphical models.
Article in Genetic epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Advances in haplotype phasing and genotype imputation.Nature reviews. Genetics · 2026Review
- SURFBAT: a surrogate family based association test building on large imputation reference panels.G3 (Bethesda, Md.) · 2025Article
- Current Developments in Detection of Identity-by-Descent Methods and Applications.Frontiers in genetics · 2021Review
- Kinpute: using identity by descent to improve genotype imputation.Bioinformatics (Oxford, England) · 2019Article
- Off the street phasing (OTSP): no hassle haplotype phasing for molecular PGD applications.Journal of assisted reproduction and genetics · 2019Article
- Article
- Article
- Article
- Computing Individual Risks Based on Family History in Genetic Disease in the Presence of Competing Risks.Computational and mathematical methods in medicine · 2017Article
- Fast and accurate long-range phasing in a UK Biobank cohort.Nature genetics · 2016Article
- Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort.European journal of human genetics : EJHG · 2015Article
- A renewal theory approach to IBD sharing.Theoretical population biology · 2014Article
- Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Article
- Using population isolates in genetic association studies.Briefings in functional genomics · 2014Review
- Reducing pervasive false-positive identical-by-descent segments detected by large-scale pedigree analysis.Molecular biology and evolution · 2014Article
- Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population.European journal of human genetics : EJHG · 2014Article
- A general approach for haplotype phasing across the full spectrum of relatedness.PLoS genetics · 2014Article
- Imputation-based assessment of next generation rare exome variant arrays.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2014Article
- Inference of identity by descent in population isolates and optimal sequencing studies.European journal of human genetics : EJHG · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Accurate knowledge of haplotypes, the combination of alleles co-residing on a single copy of a chromosome, enables powerful gene mapping and sequence imputation methods. Since humans are diploid, haplotypes must be derived from genotypes by a phasing process. In this study, we present a new computational model for haplotype phasing based on pairwise sharing of haplotypes inferred to be Identical-By-Descent (IBD). We apply the Bayesian network based model in a new phasing algorithm, called systematic long-range phasing (SLRP), that can capitalize on the close genetic relationships in isolated founder populations, and show with simulated and real genome-wide genotype data that SLRP substantially reduces the rate of phasing errors compared to previous phasing algorithms. Furthermore, the method accurately identifies regions of IBD, enabling linkage-like studies without pedigrees, and can be used to impute most genotypes with very low error rate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.