ArticleLung2011
The influence of Schizophyllum commune on asthma severity.
Article in Lung, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between sensitization to common fungi and severe asthma.Frontiers in public health · 2025Pooled it
- Dysbiosis in the Nasal Mycobiome of Infants Born in the Aftermath of Hurricane Maria.Microorganisms · 2025Article
- The Interactions of Airway Bacterial and Fungal Communities in Clinically Stable Asthma.Frontiers in microbiology · 2020Article
- Schizophyllum commune induces IL-17-mediated neutrophilic airway inflammation in OVA-induced asthma model mice.Scientific reports · 2019Article
- Schizophyllum commune-induced Pulmonary Mycosis.Chinese medical journal · 2016Article
- Filamentous Fungi in Respiratory Infections. What Lies Beyond Aspergillosis and Mucormycosis?PLoS pathogens · 2016Review
- Schizophyllum commune-induced allergic fungal rhinosinusitis and sinobronchial mycosis.Medical mycology case reports · 2015Article
- Atopic cough and fungal allergy.Journal of thoracic disease · 2014Review
- Specific detection of Bjerkandera adusta by polymerase chain reaction and its incidence in fungus-associated chronic cough.Mycopathologia · 2013Article
- Implications of high antifungal susceptibility on Schizophyllum commune-associated allergy in clinical practice.Antimicrobial agents and chemotherapy · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe sensitization and exposure to fungal allergens have been reported to be associated with asthma. The aim of this study was to clarify the impact of sensitization to Schizophyllum commune (S. commune) on the severity and exacerbations of asthma.
methodsNinety-two patients with asthma of various levels of severity [mild (n = 18), moderate (28), and severe (46)] and exacerbation severity [moderate (n = 43) and severe (6)] were retrospectively examined with regard to fungal sensitization such as specific IgE or intradermal skin reactions against S. commune and other common allergens. We also classified the patients into three groups: (1) three or more asthma attacks during the past year (F-BA) (n = 29),(2) one or two asthma attacks (NF-BA) (n = 20), and (3) no asthma attack (C-BA) (n = 43).
resultsThe positive rate of late cutaneous reactions to S. commune was higher in patients with severe asthma (41.2%) than with moderate (26.1%) or mild asthma (6.7%), and was significantly different among the three groups (P < 0.05). Although the ratio did not show a significant difference between the patients with severe (83.3%) or moderate (36.1%) exacerbation, it was higher in F-BA (60.9%) than in NF-BA (21.1%) and C-BA patients (10.0%), and it was significantly different among the three groups (P = 0.0002). Multivariate analysis identified positive results for late-phase skin reactions to S. commune and the age of the patients as an independent determinant of asthma severity, and the skin results and %FVC an independent determinant of exacerbation frequency.
conclusionThis study demonstrated that S. commune is an environmental fungus that appears to enhance both the severity of asthma and the exacerbation frequency.
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