ArticleJournal of magnetic resonance imaging : JMRI2011
Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurements.
Article in Journal of magnetic resonance imaging : JMRI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed, 98 citations in OpenAlex.
- Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.Diabetes · 2016Trial
- Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans.Diabetes care · 2015Trial
- The hallmarks of skeletal muscle health.Nature metabolism · 2026Review
- Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.The Journal of physiology · 2026Article
- Simultaneous Assessment of Skeletal Muscle Energetics and Blood Flow During Dynamic Exercise by InterleavedMagnetic resonance in medicine · 2026Article
- A Novel CEST-Based Approach for Reliably Assessing Skeletal Muscle Oxidative Phosphorylation: OXCEST.Magnetic resonance in medicine · 2026Article
- Age- and Treatment-Related Patterns in Fatigue, Coping/Resilience, and Skeletal Muscle Bioenergetics (Biomedicines · 2026Article
- Bioenergetic profiles and respiratory control in mitochondrial physiology: Precision analysis of oxidative phosphorylation.Experimental physiology · 2026Article
- Intermuscular adipose tissue in healthy human aging-effects of exercise training and implications to metabolic health.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Improvement in Insulin Sensitivity Prevents Decline in Glucose Uptake, Functional Connectivity, and Volume in the Insulin Resistant Human Brain.Research square · 2025Article
- Muscle oxidative capacity but not specific force is greater in aerobic versus resistance trained young adults.European journal of applied physiology · 2025Article
- Skeletal Muscle Quantity Versus Quality in Heart Failure: Exercise Intolerance and Outcomes in Older Patients With HFpEF Are Related to Abnormal Skeletal Muscle Metabolism Rather Than Age-Related Skeletal Muscle Loss.Circulation. Heart failure · 2025Article
- Skeletal Muscle mRNA Splicing Variants Association With Four Different Fitness and Energetic Measures in the GESTALT Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Questioning the kidney-protective effects of tolvaptan: a testable hypothesis to revisit the current narrative.Open research Europe · 2025Article
- The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechanisms of exercise intolerance and dyspnea following pediatric pulmonary embolism.Research and practice in thrombosis and haemostasis · 2025Article
- Quantitative Assessment of Peripheral Oxidative Metabolism With a New DynamicJournal of magnetic resonance imaging : JMRI · 2024Article
- Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults.GeroScience · 2024Article
- Impact of cannabis use on brain metabolism usingNeuroradiology · 2023Article
- Invasive and noninvasive markers of human skeletal muscle mitochondrial function.Physiological reports · 2023Article
- Nonequilibrium thermodynamics and mitochondrial protein content predict insulin sensitivity and fuel selection during exercise in human skeletal muscle.Frontiers in physiology · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo cross-validate skeletal muscle oxidative capacity measured by (31)P-MR spectroscopy with in vitro measurements of oxidative capacity in mitochondria isolated from muscle biopsies of the same muscle group in 18 healthy adults. MATERIALS AND
methodsOxidative capacity in vivo was determined from PCr recovery kinetics following a 30-s maximal isometric knee extension. State 3 respiration was measured in isolated mitochondria using high-resolution respirometry. A second cohort of 10 individuals underwent two (31)P-MRS testing sessions to assess the test-retest reproducibility of the method.
resultsOverall, the in vivo and in vitro methods were well-correlated (r = 0.66-0.72) and showed good agreement by Bland Altman plots. Excellent reproducibility was observed for the PCr recovery rate constant (CV = 4.6%; ICC = 0.85) and calculated oxidative capacity (CV = 3.4%; ICC = 0.83).
conclusionThese results indicate that (31)P-MRS corresponds well with gold-standard in vitro measurements and is highly reproducible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.