ArticleNeuroradiology2012
Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development.
Article in Neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05013736 (Perinatal Stroke), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery Through Neuroexcitability, Neuroimaging and Motor Development
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- White-Matter Connectivity and General Movements in Infants with Perinatal Brain Injury.Brain sciences · 2025Article
- Secondary Brain Injury Following Neonatal Intraventricular Hemorrhage: The Role of the Ciliated Ependyma.Frontiers in pediatrics · 2022Review
- Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm.Neuroradiology · 2021Article
- Early prediction of unilateral cerebral palsy in infants at risk: MRI versus the hand assessment for infants.Pediatric research · 2020Article
- Neonatal Functional and Structural Connectivity Are Associated with Cerebral Palsy at Two Years of Age.American journal of perinatology · 2020Article
- Corticospinal tract diffusion properties and robotic visually guided reaching in children with hemiparetic cerebral palsy.Human brain mapping · 2018Article
- Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats.Journal of neuroscience research · 2017Article
- Sensory tractography and robot-quantified proprioception in hemiparetic children with perinatal stroke.Human brain mapping · 2017Article
- Understanding Brain Reorganization in Infants With Perinatal Stroke Through Neuroexcitability and Neuroimaging.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association · 2017Article
- Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.NeuroImage. Clinical · 2017Review
- Neonatal DTI early after birth predicts motor outcome in preterm infants with periventricular hemorrhagic infarction.Pediatric research · 2015Article
- Motor function outcomes of pediatric patients with hemiplegic cerebral palsy after rehabilitation treatment: a diffusion tensor imaging study.Neural regeneration research · 2015Article
- Novel diffusion tensor imaging technique reveals developmental streamline volume changes in the corticospinal tract associated with leg motor control.Brain & development · 2015Article
- The effects of hemorrhagic parenchymal infarction on the establishment of sensori-motor structural and functional connectivity in early infancy.Neuroradiology · 2014Article
- Validation of a brain MRI relaxometry protocol to measure effects of preterm birth at a flexible postnatal age.BMC pediatrics · 2014Observational
- Cellular correlates of longitudinal diffusion tensor imaging of axonal degeneration following hypoxic-ischemic cerebral infarction in neonatal rats.NeuroImage. Clinical · 2014Article
- Technology-aided assessment of sensorimotor function in early infancy.Frontiers in neurology · 2014Review
- Developmental dynamics of radial vulnerability in the cerebral compartments in preterm infants and neonates.Frontiers in neurology · 2014Article
- Quantification of white matter injury following neonatal stroke with serial DTI.Pediatric research · 2013Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 4 countries.
Funding
Abstract
introductionOur aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.
methodsWe studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.
resultsConventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.
conclusionConventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.