ReviewJournal of industrial microbiology & biotechnology2012
Protein engineering towards natural product synthesis and diversification.
Review in Journal of industrial microbiology & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Protein Engineering of a Germacrene A Synthase FromFrontiers in plant science · 2022Article
- Biosynthetic engineering of the antifungal, anti-MRSA auroramycin.Microbial cell factories · 2020Article
- Iterative polyketide biosynthesis by modular polyketide synthases in bacteria.Applied microbiology and biotechnology · 2016Review
- Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates.Journal of the American Chemical Society · 2013Article
- Structural basis of functional group activation by sulfotransferases in complex metabolic pathways.ACS chemical biology · 2012Article
- Synthetic biological approaches to natural product biosynthesis.Current opinion in biotechnology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
A dazzling array of enzymes is used by nature in making structurally complex natural products. These enzymes constitute a molecular toolbox that may be used in the construction and fine-tuning of pharmaceutically active molecules. Aided by technological advancements in protein engineering, it is now possible to tailor the activities and specificities of these enzymes as biocatalysts in the production of both natural products and their unnatural derivatives. These efforts are crucial in drug discovery and development, where there is a continuous quest for more potent agents. Both rational and random evolution techniques have been utilized in engineering these enzymes. This review will highlight some examples from several large families of natural products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.