ArticleProceedings of the National Academy of Sciences of the United States of America2011
Clusters of bioactive compounds target dynamic endomembrane networks in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 130 citations in OpenAlex.
- High-throughput screening for biostimulant discovery: opportunities to enhance nitrogen use efficiency.Frontiers in plant science · 2026Review
- Novel small molecules disrupting polarized cell expansion and development in the moss,Plant biotechnology (Tokyo, Japan) · 2025Article
- SPL13 controls a root apical meristem phase change by triggering oriented cell divisions.Science (New York, N.Y.) · 2024Article
- A chemical genetic screen with the EXO70 inhibitor Endosidin2 uncovers potential modulators of exocytosis in Arabidopsis.Plant direct · 2024Article
- Four-dimensional quantitative analysis of cell plate development in Arabidopsis using lattice light sheet microscopy identifies robust transition points between growth phases.Journal of experimental botany · 2024Article
- Targeting Recycling Endosomes to Potentiate mRNA Lipid Nanoparticles.Nano letters · 2024Article
- Endosidin 5 disruption of the Golgi apparatus and extracellular matrix secretion in the unicellular charophyte Penium margaritaceum.Annals of botany · 2023Article
- An open source plant kinase chemogenomics set.Plant direct · 2022Article
- Endocytic trafficking promotes vacuolar enlargements for fast cell expansion rates in plants.eLife · 2022Article
- Cell biology of primary cell wall synthesis in plants.The Plant cell · 2022Review
- Inhibition of the Exocyst Complex with Endosidin 2 Reduces Polarized Growth inmicroPublication biology · 2022Article
- A small molecule antagonizes jasmonic acid perception and auxin responses in vascular and nonvascular plants.Plant physiology · 2021Article
- Updating Insights into the Catalytic Domain Properties of PlantMolecules (Basel, Switzerland) · 2021Review
- The chemical compound 'Heatin' stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases.The Plant journal : for cell and molecular biology · 2021Article
- A Centrifuge-Based Method for Identifying Novel Genetic Traits That Affect Root-Substrate Adhesion inFrontiers in plant science · 2021Article
- Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibit Cellulose Biosynthesis.The Plant cell · 2020Article
- CesA6 and PGIP2 Endocytosis Involves Different Subpopulations of TGN-Related Endosomes.Frontiers in plant science · 2020Article
- Article
- Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1.PloS one · 2020Article
- A Conditional Mutation inFrontiers in plant science · 2020Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Endomembrane trafficking relies on the coordination of a highly complex, dynamic network of intracellular vesicles. Understanding the network will require a dissection of cargo and vesicle dynamics at the cellular level in vivo. This is also a key to establishing a link between vesicular networks and their functional roles in development. We used a high-content intracellular screen to discover small molecules targeting endomembrane trafficking in vivo in a complex eukaryote, Arabidopsis thaliana. Tens of thousands of molecules were prescreened and a selected subset was interrogated against a panel of plasma membrane (PM) and other endomembrane compartment markers to identify molecules that altered vesicle trafficking. The extensive image dataset was transformed by a flexible algorithm into a marker-by-phenotype-by-treatment time matrix and revealed groups of molecules that induced similar subcellular fingerprints (clusters). This matrix provides a platform for a systems view of trafficking. Molecules from distinct clusters presented avenues and enabled an entry point to dissect recycling at the PM, vacuolar sorting, and cell-plate maturation. Bioactivity in human cells indicated the value of the approach to identifying small molecules that are active in diverse organisms for biology and drug discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.