ArticleProceedings of the National Academy of Sciences of the United States of America2011
Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Insights into the CD1 lipidome.Frontiers in immunology · 2024Article
- Article
- Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle.Scientific reports · 2021Article
- Remembering Enzo Cerundolo.Molecular immunology · 2021Article
- Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.Critical reviews in immunology · 2021Article
- Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection.PLoS pathogens · 2020Article
- Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.Science immunology · 2020Article
- A Direct Role for the CD1b Endogenous Spacer in the Recognition of aFrontiers in immunology · 2020Article
- Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-ResistantFrontiers in immunology · 2020Article
- A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The versatility of the CD1 lipid antigen presentation pathway.Immunology · 2018Review
- Molecular recognition of microbial lipid-based antigens by T cells.Cellular and molecular life sciences : CMLS · 2018Review
- CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis.Cell chemical biology · 2018Article
- The Conventional Nature of Non-MHC-Restricted T Cells.Frontiers in immunology · 2018Review
- A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.Science immunology · 2017Article
- CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.European journal of immunology · 2017Article
- Four pathways of CD1 antigen presentation to T cells.Current opinion in immunology · 2017Review
- CD1: From Molecules to Diseases.F1000Research · 2017Review
- Donor-unrestricted T cells in the human CD1 system.Immunogenetics · 2016Review
- The CD1 family: serving lipid antigens to T cells since the Mesozoic era.Immunogenetics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 11 institutions in 6 countries.
Funding
Abstract
The mechanisms permitting nonpolymorphic CD1 molecules to present lipid antigens that differ considerably in polar head and aliphatic tails remain elusive. It is also unclear why hydrophobic motifs in the aliphatic tails of some antigens, which presumably embed inside CD1 pockets, contribute to determinants for T-cell recognition. The 1.9-Å crystal structure of an active complex of CD1b and a mycobacterial diacylsulfoglycolipid presented here provides some clues. Upon antigen binding, endogenous spacers of CD1b, which consist of a mixture of diradylglycerols, moved considerably within the lipid-binding groove. Spacer displacement was accompanied by F' pocket closure and an extensive rearrangement of residues exposed to T-cell receptors. Such structural reorganization resulted in reduction of the A' pocket capacity and led to incomplete embedding of the methyl-ramified portion of the phthioceranoyl chain of the antigen, explaining why such hydrophobic motifs are critical for T-cell receptor recognition. Mutagenesis experiments supported the functional importance of the observed structural alterations for T-cell stimulation. Overall, our data delineate a complex molecular mechanism combining spacer repositioning and ligand-induced conformational changes that, together with pocket intricacy, endows CD1b with the required molecular plasticity to present a broad range of structurally diverse antigens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.