Trial reportThe European respiratory journal2012
Quantitative assessment of chronic lung disease of infancy using computed tomography.
Trial report in The European respiratory journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Maternal and perinatal nutritional programming of lung health and disease in childhood and early adulthood: Research gaps and opportunities-National Heart, Lung, and Blood Institute/National Institutes of Health Workshop Report.The Journal of allergy and clinical immunology · 2026Article
- Location-specific pathology analysis of monopodial airways in a rabbit model of bronchopulmonary dysplasia: a proof of principle study.BMC medical imaging · 2025Article
- Dysanapsis as a Determinant of Lung Function in Development and Disease.American journal of respiratory and critical care medicine · 2023Article
- Consequences of Preterm Birth: Knowns, Unknowns, and Barriers to Advancing Cardiopulmonary Health.Integrative and comparative biology · 2023Article
- Bronchopulmonary dysplasia from chest radiographs to magnetic resonance imaging and computed tomography: adding value.Pediatric radiology · 2022Review
- Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm.The Journal of physiology · 2022Review
- Low- and High-Attenuation Lung Volume in Quantitative Chest CT in Children without Lung Disease.Children (Basel, Switzerland) · 2021Article
- Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia.Pediatric pulmonology · 2021Review
- Early extubation to noninvasive respiratory support of former preterm lambs improves long-term respiratory outcomes.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia.Scientific reports · 2021Article
- Respiratory and cardiopulmonary limitations to aerobic exercise capacity in adults born preterm.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- Lung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants.Scientific reports · 2017Article
- Quantitative CT characterization of pediatric lung development using routine clinical imaging.Pediatric radiology · 2016Article
- Analysis of pediatric airway morphology using statistical shape modeling.Medical & biological engineering & computing · 2016Article
- Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop.The Journal of allergy and clinical immunology · 2014Article
- Advanced functional thoracic imaging in children: from basic concepts to clinical applications.Pediatric radiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The aims of this study were to determine whether infants and toddlers with chronic lung disease of infancy (CLDI) have smaller airways and lower lung density compared with full-term healthy controls. Multi-slice computed tomography (CT) chest scans were obtained at elevated lung volumes during a brief respiratory pause in sedated infants and toddlers; 38 CLDI were compared with 39 full-term controls. For CLDI subjects, gestational age at birth ranged from 25 to 29 weeks. Airway size was measured for the trachea and the next three to four generations into the right lower lobe; lung volumes and tissue density were also measured. The relationship between airway size and airway generation differed between the CLDI and full-term groups; the sizes of the first and second airway generations were larger in the shorter CLDI than in the shorter full-term subjects. The increased size in the airways in the CLDI subjects was associated with increasing mechanical ventilation time in the neonatal period. CLDI subjects had a greater heterogeneity of lung density compared with full-term subjects. Our results indicate that quantitative analysis of multi-slice CT scans at elevated volumes provides important insights into the pulmonary pathology of infants and toddlers with CLDI.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.