Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2011
Comparison of bupivacaine alone and in combination with sufentanil in patients undergoing arthroscopic knee surgery.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Intrathecal Sufentanil Does Not Reduce Shivering During Neuraxial Anesthesia: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Safety and effectiveness of adding fentanyl or sufentanil to spinal anesthesia: systematic review and meta-analysis of randomized controlled trials.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Effects of caudal sufentanil supplemented with levobupivacaine on blocking spermatic cord traction response in pediatric orchidopexy.Journal of anesthesia · 2013Trial
- Efficacy and safety of intrathecal adjuvants in lower limb orthopaedic surgery: a systematic review and network meta-analysis of randomised controlled trials.Journal of anesthesia, analgesia and critical care · 2026Review
- Postoperative Analgesic Practices and Pain Control Outcomes After Caesarean Delivery: A Cross-Sectional Survey of 215 Hospitals in Hubei Province, China.Journal of pain research · 2026Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOne disadvantage of spinal anesthesia using bupivacaine is the relatively short duration of action. Combining it with opioids can increase its analgesic effects. It was aimed to analyze the effectiveness and the side effects of bupivacaine alone and in combination with sufentanil in arthroscopic knee surgery during unilateral spinal anesthesia.
methodsThis is a prospective, randomized, double-blind trial. Fifty patients undergoing unilateral arthroscopic knee surgery were enrolled in this study. The patients were assigned into two groups to receive either 10 mg of 0.5% hyperbaric bupivacaine (Group I) or 5 mg of 0.5% hyperbaric bupivacaine combined with 2.5 μg sufentanil (Group II) to obtain unilateral spinal anesthesia.
resultsThe time for sensorial block to reach level T10 was 6.3 ± 1.7 min in Group I and 4.8 ± 1.6 min in Group II (P < 0.05). Complete motor block was obtained at the 10th min in 16 patients in Group I (P < 0.005), and the duration of the motor block was lower in Group II (4.9 ± 2.2 h and 2.0 ± 1.1 h, P < 0.001). Bradycardia was encountered in 8 patients in Group I and in 1 patient in Group II (P < 0.05). No differences were encountered regarding other side effects. During the postoperative 24 h, 5 patients in Group I and 3 patients in Group II required analgesic drugs (n.s.). There was not any significant difference between groups with regard to first analgesic request time (8.3 ± 2.4 and 9.0 ± 2.3 h, n.s.).
conclusionsThis study showed that combining lower dose bupivacaine with sufentanil provided faster onset of sensorial block and lower risk of motor block in unilateral spinal anesthesia for arthroscopic knee surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.