ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of duodenal adenocarcinoma.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis.International journal of clinical oncology · 2021Pooled it
- Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis.Annals of surgical oncology · 2018Pooled it
- Impact of extra-ampullary duodenal adenocarcinoma subtypes on surgical and oncological outcomes following pancreaticoduodenectomy.Updates in surgery · 2024Article
- Association between perineural infiltrations and delayed gastric emptying after Whipple procedure for periampullary tumours, and the relationship with other clinicopathological factors and overall survival.Przeglad gastroenterologiczny · 2024Article
- Efficacy of lymph node dissection for duodenal cancer according to the lymph node station.Annals of gastroenterological surgery · 2024Article
- Article
- Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum.World journal of gastrointestinal surgery · 2022Article
- Routine contrast-enhanced CT is insufficient for TNM-staging of duodenal adenocarcinoma.Abdominal radiology (New York) · 2022Article
- Review
- Transduodenal resection for duodenal adenomas may be an underutilized tool - A single institution experience.Heliyon · 2022Article
- Surgical results of non-ampullary duodenal cancer: a nationwide survey in Japan.Journal of gastroenterology · 2022Article
- Clinical Analysis of C-Shaped Embedded Pancreaticojejunostomy in Pancreaticoduodenectomy.Journal of oncology · 2022Article
- Prognostic factors for long-term survival after pancreaticoduodenectomy for periampullary adenocarcinoma. A retrospective cohort study.Annals of medicine and surgery (2012) · 2020Article
- Tumour stage and resection margin status are independent survival factors following partial pancreatoduodenectomy for duodenal adenocarcinoma.Langenbeck's archives of surgery · 2019Article
- Elevated baseline serum lactate dehydrogenase indicates a poor prognosis in primary duodenum adenocarcinoma patients.Journal of Cancer · 2018Article
- Duodenal adenocarcinoma: Advances in diagnosis and surgical management.World journal of gastrointestinal surgery · 2016Review
- Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China.BioMed research international · 2016Article
- Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum: A case report.Oncology letters · 2016Article
- Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma.PloS one · 2016Article
- Widespread lymph node recurrence of major duodenal papilla cancer following pancreaticoduodenectomy.World journal of gastroenterology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnlike other gastrointestinal tumors, lymph node involvement has not consistently been a negative prognostic factor for survival in patients with duodenal adenocarcinoma. Our aim is to examine prognostic factors in patients who underwent a curative resection of their duodenal adenocarcinoma.
methodsA retrospective review of 169 patients diagnosed with primary duodenal lesions between 1982 and 2010 was performed, of whom 103 were treated with curative intent. Clinico-pathologic factors were evaluated.
resultsA potentially curative resection was performed in 103 patients with a median age of 67 years (range, 22-91). Perineural and lympho-vascular invasion were identified in 30 (29.1%) and 39 patients (37.9%), respectively. Median follow-up was 26.5 months. The 5-year overall survival was 62% vs. 25% for patients with or without nodal metastases (p < 0.001) and 56% vs. 19% for patients with or without perineural invasion (p < 0.001), respectively. Lymph node ratio, type of resection, and size of tumor failed to stratify prognosis. By multivariate analysis, perineural invasion was the most powerful independent predictor of survival (HR, 2.520; CI, 1.361-4.664).
conclusionsPerineural invasion is a stronger predictor for recurrence and survival than tumor size, depth of infiltration, lymph node involvement, and type of resection in patients with duodenal adenocarcinoma.
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