ArticleEuropean journal of nuclear medicine and molecular imaging2012
Coronary risk factors and myocardial blood flow in patients evaluated for coronary artery disease: a quantitative [15O]H2O PET/CT study.
Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Pooled it
- Added value of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- Impairment of subendocardial perfusion reserve and oxidative metabolism in nonischemic dilated cardiomyopathy.Journal of cardiac failure · 2013Trial
- Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes.Cardiovascular diabetology · 2025Observational
- Derivation and validation of an artificial intelligence-based plaque burden safety cut-off for long-term acute coronary syndrome from coronary computed tomography angiography.European heart journal. Cardiovascular Imaging · 2025Article
- Relationship between microvascular status and diagnostic performance of stress dynamic CT perfusion imaging.European radiology · 2025Article
- Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study.Cardiovascular diabetology · 2025Article
- Impact of cardiac history and myocardial scar on increase of myocardial perfusion after revascularization.European journal of nuclear medicine and molecular imaging · 2023Article
- Characterizing the Bone Marrow Environment in Advanced-Stage Myelofibrosis during Ruxolitinib Treatment Using PET/CT and MRI: A Pilot Study.Tomography (Ann Arbor, Mich.) · 2023Article
- The impact of coronary revascularization on vessel-specific coronary flow capacity and long-term outcomes: a serial [15O]H2O positron emission tomography perfusion imaging study.European heart journal. Cardiovascular Imaging · 2022Article
- A Novel Quantitative Parameter for Static Myocardial Computed Tomography: Myocardial Perfusion Ratio to the Aorta.Journal of clinical medicine · 2022Article
- Coronary Microvascular Disease.Cardiology and therapy · 2022Review
- Coronary artery stenosis-related perfusion ratio using dynamic computed tomography myocardial perfusion imaging: a pilot for identification of hemodynamically significant coronary artery disease.Cardiovascular intervention and therapeutics · 2020Observational
- Computed tomographic myocardial mass compared with invasive myocardial perfusion measurement.Heart (British Cardiac Society) · 2020Article
- Incremental prognostic value of hybrid [15O]H2O positron emission tomography-computed tomography: combining myocardial blood flow, coronary stenosis severity, and high-risk plaque morphology.European heart journal. Cardiovascular Imaging · 2020Article
- Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up.Medical physics · 2017Article
- Single-scan rest/stress imaging: validation in a porcine model withEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Coronary atherosclerotic burden vs. coronary vascular function in diabetic and nondiabetic patients with normal myocardial perfusion: a propensity score analysis.European journal of nuclear medicine and molecular imaging · 2017Article
- Myocardial perfusion imaging with PET.The international journal of cardiovascular imaging · 2017Review
- Quantitative assessment of myocardial blood flow in coronary artery disease by cardiovascular magnetic resonance: comparison of Fermi and distributed parameter modeling against invasive methods.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere has been increasing interest in quantitative myocardial blood flow (MBF) imaging over the last years and it is expected to become a routinely used technique in clinical practice. Positron emission tomography (PET) using [(15)O]H(2)O is the established gold standard for quantification of MBF in vivo. A fundamental issue when performing quantitative MBF imaging is to define the limits of MBF in a clinically suitable population. The aims of the present study were to determine the limits of MBF and to determine the relationship among coronary artery disease (CAD) risk factors, gender and MBF in a predominantly symptomatic patient cohort without significant CAD.
methodsA total of 128 patients (mean age 54 ± 10 years, 50 men) with a low to intermediate pretest likelihood of CAD were referred for noninvasive evaluation of CAD using a hybrid PET/computed tomography (PET/CT) scanner. MBF was quantified with [(15)O]H(2)O at rest and during adenosine-induced hyperaemia. Obstructive CAD was excluded in these patients by means of invasive or CT-based coronary angiography.
resultsGlobal average baseline MBF values were 0.91 ± 0.34 and 1.09 ± 0.30 ml·min(-1)·g(-1) (range 0.54-2.35 and 0.59-2.75 ml·min(-1)·g(-1)) in men and women, respectively (p < 0.01). However, no gender-dependent difference in baseline MBF was seen following correction for rate-pressure product (0.98 ± 0.45 and 1.09 ± 0.30 ml·min(-1)·g(-1) in men and women, respectively; p = 0.08). Global average hyperaemic MBF values were 3.44 ± 1.20 ml·min(-1)·g(-1) in the whole study population, and 2.90 ± 0.85 and 3.78 ± 1.27 ml·min(-1)·g(-1) (range 1.52-5.22 and 1.72-8.15 ml·min(-1)·g(-1)) in men and women, respectively (p < 0.001). Multivariate analysis identified male gender, age and body mass index as having an independently negative impact on hyperaemic MBF.
conclusionGender, age and body mass index substantially influence reference values and should be corrected for when interpreting hyperaemic MBF values.
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