ArticleThe Journal of physiology2011
Analysis of pacemaker activity in the human stomach.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Electrogastrography measurement systems and analysis methods used in clinical practice and research: comprehensive review.Frontiers in medicine · 2024Pooled it
- Intragastric Botulinum Toxin A Injection Is an Effective Obesity Therapy for Patients with BMI > 40 kg/mObesity surgery · 2020Pooled it
- Gastric Biofeedback in Virtual Reality: Feasibility, Efficacy and Self-Reported Experience.Applied psychophysiology and biofeedback · 2026Trial
- EUS-Guided Intragastric Injection of Botulinum Toxin A in the Preoperative Treatment of Super-Obese Patients: a Randomized Clinical Trial.Obesity surgery · 2019Trial
- Gastroparesis Phenotyping: Current Methods and Emerging Opportunities With Magnetic Resonance Imaging.Neurogastroenterology and motility · 2026Review
- Differential responses to prostaglandins in the circular and longitudinal muscle layers of the murine ileum.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Pyloric Dysfunction: A Review of the Mechanisms, Diagnosis, and Treatment.Gut and liver · 2025Review
- Surface mapping of gastric motor functions using MRI: a comparative study between humans and rats.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Isoflurane anesthesia suppresses gastric myoelectric power in the ferret.Neurogastroenterology and motility · 2024Article
- Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsy Samples in Patients With Gastroparesis Ready for Prime Time?Gastroenterology · 2023Article
- Mfge8 is expressed by pericytes in gastric antrum submucosa from patients with obesity.American journal of physiology. Cell physiology · 2023Article
- Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea.British journal of pharmacology · 2022Article
- Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission.The Journal of physiology · 2022Article
- Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract.World journal of gastrointestinal surgery · 2022Review
- Gastroparesis.Gastroenterology · 2022Review
- Mfge8 attenuates human gastric antrum smooth muscle contractions.Journal of muscle research and cell motility · 2021Article
- Electrogastrography in Autonomous Vehicles-An Objective Method for Assessment of Motion Sickness in Simulated Driving Environments.Sensors (Basel, Switzerland) · 2021Article
- Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches.Frontiers in neuroscience · 2021Review
- Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility.International journal of molecular sciences · 2020Review
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10 authors.
Funding
Abstract
Extracellular electrical recording and studies using animal models have helped establish important concepts of human gastric physiology. Accepted standards include electrical quiescence in the fundus, 3 cycles per minute (cpm) pacemaker activity in corpus and antrum, and a proximal-to-distal slow wave frequency gradient. We investigated slow wave pacemaker activity, contractions and distribution of interstitial cells of Cajal (ICC) in human gastric muscles. Muscles were obtained from patients undergoing gastric resection for cancer, and the anatomical locations of each specimen were mapped by the operating surgeon to 16 standardized regions of the stomach. Electrical slow waves were recorded with intracellular microelectrodes and contractions were recorded by isometric force techniques. Slow waves were routinely recorded from gastric fundus muscles. These events had similar waveforms as slow waves in more distal regions and were coupled to phasic contractions. Gastric slow wave frequency was significantly greater than 3 cpm in all regions of the stomach. Antral slow wave frequency often exceeded the highest frequency of pacemaker activity in the corpus. Chronotropic mechanisms such as muscarinic and prostaglandin receptor binding, stretch, extracelluar Ca(2+) and temperature were unable to explain the observed slow wave frequency that exceeded accepted normal levels. Muscles from all regions through the thickness of the muscularis demonstrated intrinsic pacemaker activity, and this corresponded with the widespread distribution in ICC we mapped throughout the tunica muscularis. Our findings suggest that extracellular electrical recording has underestimated human slow wave frequency and mechanisms of human gastric function may differ from standard laboratory animal models.
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