ArticleThe Journal of physiology2011
Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 31 citations in OpenAlex.
- Amyloid Precursor Protein Processing Links Female Urgency Urinary Incontinence with Alzheimer's Disease: Implications for Treatment.International journal of molecular sciences · 2026Article
- Superficial peroneal neuromodulation of nonobstructive urinary retention induced by prolonged pudendal afferent activity in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Superficial peroneal neuromodulation of persistent bladder underactivity induced by prolonged pudendal afferent nerve stimulation in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- State-dependent bioelectronic interface to control bladder function.Scientific reports · 2021Article
- Bladder underactivity induced by prolonged pudendal afferent activity in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Additive Inhibition of Reflex Bladder Activity Induced by Bilateral Pudendal Neuromodulation in Cats.Frontiers in neuroscience · 2020Article
- Spinal interneuronal mechanisms underlying pudendal and tibial neuromodulation of bladder function in cats.Experimental neurology · 2018Article
- Stimulation of the sensory pudendal nerve increases bladder capacity in the rat.American journal of physiology. Renal physiology · 2018Article
- Efficacy of different spinal nerve roots for neuromodulation of micturition reflex in rats.Oncotarget · 2018Article
- Sacral neuromodulation blocks pudendal inhibition of reflex bladder activity in cats: insight into the efficacy of sacral neuromodulation in Fowler's syndrome.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Lumbosacral spinal segmental contributions to tibial and pudendal neuromodulation of bladder overactivity in cats.Neurourology and urodynamics · 2017Article
- Glutamatergic Mechanisms Involved in Bladder Overactivity and Pudendal Neuromodulation in Cats.The Journal of pharmacology and experimental therapeutics · 2017Article
- Sex difference in the contribution of GABAAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Neurotransmitter Mechanisms Underlying Sacral Neuromodulation of Bladder Overactivity in Cats.Neuromodulation : journal of the International Neuromodulation Society · 2017Article
- Sympathetic β-adrenergic mechanism in pudendal inhibition of nociceptive and non-nociceptive reflex bladder activity.American journal of physiology. Renal physiology · 2016Article
- Pudendal but not tibial nerve stimulation inhibits bladder contractions induced by stimulation of pontine micturition center in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Role of spinal metabotropic glutamate receptor 5 in pudendal inhibition of the nociceptive bladder reflex in cats.American journal of physiology. Renal physiology · 2015Article
- Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury.The journal of spinal cord medicine · 2015Review
- Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function.Bioelectronic medicine · 2015Article
- Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
This study used MTEP, a metabotropic glutamate receptor 5 (mGluR5) antagonist, to examine the role of mGluR5 in the neural control of the urinary bladder and in the inhibition of the micturition reflex by pudendal nerve stimulation (PNS). Experiments were conducted in 11 female cats under α-chloralose anaesthesia when the bladder was infused with either saline or 0.25% acetic acid (AA). AA irritated the bladder, induced bladder overactivity and significantly (P < 0.001) reduced bladder capacity to 14.9 ± 10.3% of the saline control capacity. MTEP (0.1-50 mg kg(-1), i.v.) significantly (P < 0.05) increased bladder capacity during saline distension but not during AA irritation. However, MTEP induced a transient inhibition of isovolumetric bladder contractions under both conditions. PNS (5 Hz), which was tested at the threshold (T) intensity for inducing a complete inhibition of isovolumetric bladder contractions and at an intensity of 3-4T, suppressed AA-induced bladder overactivity and significantly increased bladder capacity to 68.0 ± 31.3% at 1T (P < 0.05) and 98.5 ± 55.3% at 3-4T (P < 0.01) of the saline control capacity. MTEP dose dependently (0.1-50 mg kg(-1), i.v.) suppressed PNS inhibition of bladder overactivity at low intensity (1T) but not at high intensity (3-4T). During saline infusion PNS significantly (P < 0.05) increased bladder capacity to 167.7 ± 27.1% at 1T and 196.0 ± 37.4% at 3-4T. These inhibitory effects were not observed after MTEP (0.1-50 mg kg(-1), i.v.) which also increased bladder capacity. These results indicate that glutamic acid has a transmitter function in bladder and somato-bladder reflex mechanisms and raise the possibility that mGluR5 may be a target for pharmacological treatment of lower urinary tract disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.