ReviewThe Journal of physiology2011
Redefining the components of central CO2 chemosensitivity--towards a better understanding of mechanism.
Review in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
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- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer.Clinical and experimental medicine · 2024Review
- Chloride Modulates Central pH Sensitivity and Plasticity of Brainstem Breathing-Related Biorhythms in Zebra Finch Embryos.Developmental psychobiology · 2024Article
- Influence of hypercapnia and hypercapnic hypoxia on the heart rate response to apnea.Physiological reports · 2024Article
- Whole-brain analysis of CObioRxiv : the preprint server for biology · 2023Article
- Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice.eLife · 2022Article
- Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022Review
- The subfornical organ regulates acidosis-evoked fear by engaging microglial acid-sensor TDAG8 and forebrain neurocircuits in male mice.Journal of neuroscience research · 2022Article
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Neuroimmune mechanisms in fear and panic pathophysiology.Frontiers in psychiatry · 2022Review
- COInterface focus · 2021Review
- Connexin26 mediates COCommunications biology · 2020Article
- A Physiological Overview of the Demands, Characteristics, and Adaptations of Highly Trained Artistic Swimmers: a Literature Review.Sports medicine - open · 2019Review
- Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons.The Journal of physiology · 2019Article
- The Role Of Parafacial Neurons In The Control Of Breathing During Exercise.Scientific reports · 2018Article
- Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus.PLoS computational biology · 2017Article
- Modulation of sensory information processing by a neuroglobin inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Differential behavioral sensitivity to carbon dioxide (CONeuroscience · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The field of CO(2) chemosensitivity has developed considerably in recent years. There has been a mounting number of competing nuclei proposed as chemosensitive along with an ever increasing list of potential chemosensory transducing molecules. Is it really possible that all of these areas and candidate molecules are involved in the detection of chemosensory stimuli? How do we discriminate rigorously between molecules that are chemosensory transducers at the head of a physiological reflex versus those that just happen to display sensitivity to a chemosensory stimulus? Equally, how do we differentiate between nuclei that have a primary chemosensory function, versus those that are relays in the pathway? We have approached these questions by proposing rigorous definitions for the different components of the chemosensory reflex, going from the salient molecules and ions, through the components of transduction to the identity of chemosensitive cells and chemosensitive nuclei. Our definitions include practical and rigorous experimental tests that can be used to establish the identity of these components. We begin by describing the need for central CO(2) chemosensitivity and the problems that the field has faced. By comparing chemosensory mechanisms to those in the visual system we suggest stricter definitions for the components of the chemosensory pathway. We then, considering these definitions, re-evaluate current knowledge of chemosensory transduction, and propose the 'multiple salient signal hypothesis' as a framework for understanding the multiplicity of transduction mechanisms and brain areas seemingly involved in chemosensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.