ArticleCells, tissues, organs2012
A novel ovine ex vivo arteriovenous shunt model to test vascular implantability.
Article in Cells, tissues, organs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Concise Review: Patency of Small-Diameter Tissue-Engineered Vascular Grafts: A Meta-Analysis of Preclinical Trials.Stem cells translational medicine · 2019Pooled it
- Preliminary in-silico analysis of vascular graft implantation configuration and surface modification.Scientific reports · 2023Article
- Hair Follicle Stem Cells for Tissue Regeneration.Tissue engineering. Part B, Reviews · 2022Review
- Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering.Journal of cardiovascular development and disease · 2021Review
- Extracellular Matrix for Small-Diameter Vascular Grafts.Tissue engineering. Part A · 2020Review
- Regenerative and durable small-diameter graft as an arterial conduit.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Current Strategies for the Manufacture of Small Size Tissue Engineering Vascular Grafts.Frontiers in bioengineering and biotechnology · 2018Review
- Article
- The Tissue-Engineered Vascular Graft-Past, Present, and Future.Tissue engineering. Part B, Reviews · 2016Article
- Successful endothelialization and remodeling of a cell-free small-diameter arterial graft in a large animal model.Biomaterials · 2016Article
- Capture of endothelial cells under flow using immobilized vascular endothelial growth factor.Biomaterials · 2015Article
- Arterial grafts exhibiting unprecedented cellular infiltration and remodeling in vivo: the role of cells in the vascular wall.Biomaterials · 2015Article
- Surgical technique for the implantation of tissue engineered vascular grafts and subsequent in vivo monitoring.Journal of visualized experiments : JoVE · 2015Article
- Animal models for vascular tissue-engineering.Current opinion in biotechnology · 2013Review
- Differential and synergistic effects of mechanical stimulation and growth factor presentation on vascular wall function.Biomaterials · 2013Article
- Hair follicle: a novel source of multipotent stem cells for tissue engineering and regenerative medicine.Tissue engineering. Part B, Reviews · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The major objective of successful development of tissue-engineered vascular grafts is long-term in vivo patency. Optimization of matrix, cell source, surface modifications, and physical preconditioning are all elements of attaining a compatible, durable, and functional vascular construct. In vitro model systems are inadequate to test elements of thrombogenicity and vascular dynamic functional properties while in vivo implantation is complicated, labor-intensive, and cost-ineffective. We proposed an ex vivo ovine arteriovenous shunt model in which we can test the patency and physical properties of vascular grafts under physiologic conditions. The pressure, flow rate, and vascular diameter were monitored in real-time in order to evaluate the pulse wave velocity, augmentation index, and dynamic elastic modulus, all indicators of graft stiffness. Carotid arteries, jugular veins, and small intestinal submucosa-based grafts were tested. SIS grafts demonstrated physical properties between those of carotid arteries and jugular veins. Anticoagulation properties of grafts were assessed via scanning electron microscopy imaging, en face immunostaining, and histology. Luminal seeding with endothelial cells greatly decreased the attachment of thrombotic components. This model is also suture free, allowing for multiple samples to be stably processed within one animal. This tunable (pressure, flow, shear) ex vivo shunt model can be used to optimize the implantability and long-term patency of tissue-engineered vascular constructs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.