ReviewCurrent opinion in genetics & development2011
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
Review in Current opinion in genetics & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Barcodes based on nucleic acid sequences: Applications and challenges (Review).Molecular medicine reports · 2025Review
- Article
- Single-cell analyses reveal increased gene expression variability in human neurodevelopmental conditions.American journal of human genetics · 2025Article
- Exploring the Surface: Sampling of Potential Skin Cancer Biomarkers Kynurenine and Tryptophan, Studied on 3D Melanocyte and Melanoma Models.Biomolecules · 2024Article
- CRIPTO-based micro-heterogeneity of mouse muscle satellite cells enables adaptive response to regenerative microenvironment.Developmental cell · 2023Article
- Resolving Crosstalk Between Signaling Pathways Using Mathematical Modeling and Time-Resolved Single Cell Data.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Modeling Cellular Signaling Variability Based on Single-Cell Data: The TGFβ-SMAD Signaling Pathway.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells.Cellular oncology (Dordrecht, Netherlands) · 2022Article
- Origin of Cancer: Cell work is the Key to Understanding Cancer Initiation and Progression.Frontiers in cell and developmental biology · 2022Article
- A top-down measure of gene-to-gene coordination for analyzing cell-to-cell variability.Scientific reports · 2021Article
- SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors.Cell death & disease · 2021Article
- Rapidly dynamic host cell heterogeneity in bacterial adhesion governs susceptibility to infection byMolecular biology of the cell · 2020Article
- A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.PLoS computational biology · 2020Article
- Quantification of the dynamics of population heterogeneities in CHO cultures with stably integrated fluorescent markers.Analytical and bioanalytical chemistry · 2020Article
- Stem Cell Signaling Pathways in the Small Intestine.International journal of molecular sciences · 2020Review
- Article
- Article
- Gene expression distribution deconvolution in single-cell RNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation.Cell metabolism · 2018Article
- Automated cell cycle and cell size measurements for single-cell gene expression studies.BMC research notes · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The human body is formed by trillions of individual cells. These cells work together with remarkable precision, first forming an adult organism out of a single fertilized egg, and then keeping the organism alive and functional for decades. To achieve this precision, one would assume that each individual cell reacts in a reliable, reproducible way to a given input, faithfully executing the required task. However, a growing number of studies investigating cellular processes on the level of single cells revealed large heterogeneity even among genetically identical cells of the same cell type. Here we discuss the sources of heterogeneity in mammalian systems; how cells ensure reliable processing of information despite fluctuations in their molecular components; and what could be the benefit of cell-to-cell variability for mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.