Evidence map›Paper›PMID 22005576›Full record

ArticleNeuroscience letters2011

Interdependence of measures in pavlovian conditioned freezing.

Suzanne C Wood, Stephan G Anagnostaras

Abstract read
In one paragraph

Article in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Article
  7. Article
  8. The Neurobiology of Fear Generalization.Frontiers in behavioral neuroscience · 2018
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  10. The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Article
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  13. Article
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  15. Animal model of methylphenidate's long-term memory-enhancing effects.Learning & memory (Cold Spring Harbor, N.Y.) · 2014
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Suzanne C WoodThe Learning Lab, Department of Psychology, Columbia University, New York, NY 10027, USA. swg2111@columbia.edu
Stephan G Anagnostaras

Funding

Neural Correlate of Associative Memory Following Amphetamine AdministrationF31DA026259 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WOOD, SUZANNE · 2009 to 2010
$57k
NIDA NIH HHS DA026259NIDA NIH HHS F31 DA026259
6 · The paper itself

Abstract

Pavlovian conditioned freezing is an intensively utilized paradigm that has become a standard model of memory and cognition. Despite its widespread use, the interdependence among each measure commonly reported in fear conditioning studies has not been described. Using mice, we examine the relationship of each common freezing measure (Training Baseline, Post-Shock freezing, Contextual Fear, Tone Baseline, and Tone Fear), as well as baseline locomotor activity measures, to better understand the significance of each. Of particular interest, Post-Shock freezing appears to be a good measure of immediate contextual memory. In contrast, Tone Baseline freezing, as typically measured in a novel context, appears to be contaminated with multiple sources of fear. Finally, Contextual and Tone Fear show a weak interdependence.

Indexed as

AnimalsAvoidance LearningConditioning, ClassicalCuesElectroshockFearFemaleFreezing Reaction, CatalepticMaleMiceMice, 129 StrainMice, Inbred C57BLRadiation Chimera

Identifiers

PMID22005576
PMCPMC3215911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.