ArticleThe Kaohsiung journal of medical sciences2011
The effects of labor on differential gene expression in parturient women, placentas, and fetuses at term pregnancy.
Article in The Kaohsiung journal of medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Molecular Mechanism and Pathways of Normal Human Parturition in Different Gestational Tissues: A Systematic Review of Transcriptome Studies.Frontiers in physiology · 2021Pooled it
- Gestational tissue transcriptomics in term and preterm human pregnancies: a systematic review and meta-analysis.BMC medical genomics · 2015Pooled it
- Umbilical Cord Blood Biomarkers for Early Risk Stratification of Childhood Asthma and Atopic Dermatitis: A Developmental and Critical Appraisal.Journal of asthma and allergy · 2026Review
- The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma.Scientific reports · 2023Article
- Contribution of labor related gene subtype classification on heterogeneity of polycystic ovary syndrome.PloS one · 2023Article
- Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study.Geburtshilfe und Frauenheilkunde · 2021Article
- Hypoxia-Induced Alpha-Globin Expression in Syncytiotrophoblasts Mimics the Pattern Observed in Preeclamptic Placentas.International journal of molecular sciences · 2021Article
- Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity.Archives of gynecology and obstetrics · 2021Article
- Differences in maternal gene expression in Cesarean section delivery compared with vaginal delivery.Scientific reports · 2020Article
- Gestational Age-Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics.Drug metabolism and disposition: the biological fate of chemicals · 2020Article
- Placental expression of imprinted genes varies with sampling site and mode of delivery.Placenta · 2015Article
- Paraoxonase 2 protein is spatially expressed in the human placenta and selectively reduced in labour.PloS one · 2014Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Labor and its associated pain are thought to have unique impacts on parturient women. The goal of this study was to investigate the effects of labor and associated pain on differential gene expression profiles in the maternal, fetal, and placental compartments. We used microarrays to analyze maternal blood (MB), fetal cord blood (CB), and placental tissue samples in pregnant women after term vaginal deliveries (laboring group) and in term pregnant women after scheduled Ceasarean sections (nonlaboring group). The upregulated genes in the MB of the laboring group are involved in cytokine and nuclear factor-kappa B signaling pathways, regulation of the networks of toll-like receptor 4, and suppressor of cytokine signaling 3. Upregulated genes in the CB of the laboring group are involved in responding to stress and stimuli by regulating the network genes of the T-cell receptor beta locus and the FK506 binding protein 8. Differentially expressed genes in the placenta of the laboring group are involved in nitric oxide transport, gas transport, response to hydrostatic pressure, oxygen transport, acute phase responses, and the tumor necrosis factor-mediated signaling pathway, which are important during the transient hypoxemia and hypoperfusion that occur in the placenta during uterine contractions. Interestingly, few of the genes exhibited simultaneous changes in all three compartments, indicating that different pathways and complex interactions may be involved in human labor. In conclusion, human labor and its associated pain elicit unique gene regulatory changes in MB, placenta, and CB.
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Registered trials
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