Trial reportBehavioural brain research2012
Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania.
Trial report in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial.BMC psychiatry · 2021Trial
- The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients.Molecular pain · 2015Trial
- Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study.Psychiatry research · 2013Trial
- Neurofunctional Correlates of Response to Quetiapine in Adolescents with Bipolar Depression.Journal of child and adolescent psychopharmacologyTrial
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Cognitive and Affective Empathy as Indirect Paths Between Heterogeneous Depression Symptoms on Default Mode and Salience Network Connectivity in Adolescents.Child psychiatry and human development · 2023Article
- Identification of common neural substrates with connectomic abnormalities in four major psychiatric disorders: A connectome-wide association study.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Identification of Common Thalamocortical Dysconnectivity in Four Major Psychiatric Disorders.Schizophrenia bulletin · 2019Article
- Increased Alpha Band Functional Connectivity Following the Quadrato Motor Training: A Longitudinal Study.Frontiers in human neuroscience · 2017Article
- Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Effect of Pharmacological Interventions on the Fronto-Cingulo-Parietal Cognitive Control Network in Psychiatric Disorders: A Transdiagnostic Systematic Review of fMRI Studies.Frontiers in psychiatry · 2016Review
- Facial emotion recognition in childhood-onset bipolar I disorder: an evaluation of developmental differences between youths and adults.Bipolar disorders · 2015Article
- Rapid-response impulsivity: definitions, measurement issues, and clinical implications.Personality disorders · 2015Review
- Early signs of anomalous neural functional connectivity in healthy offspring of parents with bipolar disorder.Bipolar disorders · 2014Article
- Differentiating patterns of amygdala-frontal functional connectivity in schizophrenia and bipolar disorder.Schizophrenia bulletin · 2014Article
- Differential Anterior Cingulate Activity during Response Inhibition in Depressed Adolescents with Bipolar and Unipolar Major Depressive Disorder.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2014Article
- Nucleus accumbens responses differentiate execution and restraint in reward-directed behavior.Journal of neurophysiology · 2014Article
- Psychosocial intervention for pediatric bipolar disorder: current and future directions.Expert review of neurotherapeutics · 2013Article
- The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012Review
- Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder.Bipolar disorders · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of the current study was to determine the influence of implicated affective circuitry disturbance in pediatric bipolar disorder (PBD) on behavioral inhibition. The differential influence of an antipsychotic and an anti-epileptic medication on the functional connectivity across affective and cognitive neural operations in PBD was examined.
methodsThis was a six-week double blind randomized fMRI trial of risperidone plus placebo vs. divalproex plus placebo for patients with mania (n=22; 13.6 ± 2.5 years). Healthy controls (HC; n=14, 14.5 ± 2.8 years) were also scanned for normative comparison. Participants performed a response inhibition fMRI task where a motor response, already 'on the way' to execution, had to be voluntarily inhibited on trials where a stop signal was presented. Independent component analysis was used to map functional connectivity across the whole brain.
resultsWhile there were no behavioral differences between the groups at pre- or post-drug trial, there was significant improvement on manic symptoms in the patient groups. All participants engaged an evaluative affective circuit (EAC: bilateral inferior frontal gyrus, middle frontal gyrus, anterior cingulate cortex (ACC), middle temporal gyrus, insulae, caudate and putamen) and a reactive affective circuit (RAC: bilateral occipital cortex, amygdala, medial frontal gyrus and insula) during task performance. Within the EAC, post-treatment and relative to HC, greater engagement was seen in left insula in risperidone group and left subgenual ACC in divalproex group. Within the RAC, greater baseline amygdala connectivity in patients did not alter with treatment.
conclusionEAC and RAC are two key circuits that moderate emotional influence on response inhibition in PBD. Risperidone and divalproex differentially engage the EAC. Limited change in amygdala activity with treatment in all patients indicates a likely trait deficit in PBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.