ArticleJournal of autoimmunity2012
Regulatory T cells protect from autoimmune arthritis during pregnancy.
Article in Journal of autoimmunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- A GDF-15-GFRAL axis controls autoimmune T cell responses during neuroinflammation.Nature immunology · 2026Article
- Helper T cells: A potential target for sex hormones to ameliorate rheumatoid arthritis? (Review).Molecular medicine reports · 2024Review
- Regulatory T cell-derived enkephalin gates nociception.bioRxiv : the preprint server for biology · 2024Article
- Alterations of NK Cell Phenotype During Pregnancy in Multiple Sclerosis.Frontiers in immunology · 2022Article
- Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring.Immunity · 2021Article
- NF-κB regulation in maternal immunity during normal and IUGR pregnancies.Scientific reports · 2021Article
- Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?Immunometabolism · 2021Article
- T helper cell immunity in pregnancy and influence on autoimmune disease progression.Journal of autoimmunity · 2021Review
- Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity.Nature reviews. Rheumatology · 2020Review
- Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease.Frontiers in immunology · 2020Review
- Immunological Basis for Recurrent Fetal Loss and Pregnancy Complications.Annual review of pathology · 2019Review
- Cross-reactive Dengue virus-specific CD8Nature communications · 2018Article
- T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy.Cancer immunology, immunotherapy : CII · 2018Review
- Regulatory T-Cells Mediate IFN-α-Induced Resistance against Antigen-Induced Arthritis.Frontiers in immunology · 2018Article
- Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis.Theranostics · 2018Article
- T-Cell Mediation of Pregnancy Analgesia Affecting Chronic Pain in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Pregnancy and multiple sclerosis: from molecular mechanisms to clinical application.Seminars in immunopathology · 2016Review
- Immunology of hepatic diseases during pregnancy.Seminars in immunopathology · 2016Review
- The T helper type 17/regulatory T cell paradigm in pregnancy.Immunology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Pregnancy frequently has a beneficial effect on the autoimmune disease Rheumatoid Arthritis, ranging from improvement in clinical symptoms to complete remission. Despite decades of study, a mechanistic explanation remains elusive. Here, we demonstrate that an analogous pregnancy-induced remission can be observed in a mouse model of arthritis. We demonstrate that during pregnancy mice are protected from collagen-induced arthritis, but are still capable of launching normal immune responses to influenza infections. We examine the role of regulatory T (T(R)) cells in this beneficial effect. T(R) cells are essential for many aspects of immune tolerance, including the suppression of autoimmune responses. Remarkably, transfer of regulatory T cells from pregnant 'protected' mice was sufficient to confer protection to non-pregnant mice. These results suggest that regulatory T cells are responsible for the pregnancy-induced amelioration of arthritis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.