ArticleBiophysical journal2011
GB1 is not a two-state folder: identification and characterization of an on-pathway intermediate.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- DreamFold: A World Model to efficiently generate protein folding pathways in the latent space.Protein science : a publication of the Protein Society · 2026Article
- Context-Aware Hydrophobicity Modeling: HydroMap and FastHydroMap.bioRxiv : the preprint server for biology · 2026Article
- Topological determinants in protein folding dynamics: a comparative analysis of metamorphic proteins.Biology direct · 2025Article
- Protein Binding Leads to Reduced Stability and Solvated Disorder in the Polystyrene Nanoparticle Corona.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Effects of ionic strength on the folding and stability of SAMP1, a ubiquitin-like halophilic protein.Biophysical journal · 2022Article
- Dried Protein Structure Revealed at the Residue Level by Liquid-Observed Vapor Exchange NMR.Biochemistry · 2021Article
- Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches.PLoS computational biology · 2016Article
- Structural Determinants of Misfolding in Multidomain Proteins.PLoS computational biology · 2016Article
- Complex pathways in folding of protein G explored by simulation and experiment.Biophysical journal · 2014Article
- Residue level quantification of protein stability in living cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Engineered solubility tag for solution NMR of proteins.Protein science : a publication of the Protein Society · 2013Article
- Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Folding pathways of proteins with increasing degree of sequence identities but different structure and function.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Single-molecule fluorescence experiments determine protein folding transition path times.Science (New York, N.Y.) · 2012Article
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Authors and funding
7 authors.
Funding
Abstract
The folding pathway of the small α/β protein GB1 has been extensively studied during the past two decades using both theoretical and experimental approaches. These studies provided a consensus view that the protein folds in a two-state manner. Here, we reassessed the folding of GB1, both by experiments and simulations, and detected the presence of an on-pathway intermediate. This intermediate has eluded earlier experimental characterization and is distinct from the collapsed state previously identified using ultrarapid mixing. Failure to identify the presence of an intermediate affects some of the conclusions that have been drawn for GB1, a popular model for protein folding studies.
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