ArticleBiophysical journal2011
Magnetic manipulation of nanorods in the nucleus of living cells.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Direct mechanical communication of cellular to nuclear shapes in oocytes.Biophysical journal · 2026Article
- Centromeres and telomeres as rheological probes of the human cell nucleus.Biophysical journal · 2026Article
- Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.Annual review of biomedical engineering · 2026Review
- Heterogeneity as a feature: unraveling chromatin's role in nuclear mechanics.Nucleus (Austin, Tex.) · 2025Review
- Autonomous Nanorobots as Miniaturized Surgeons for Intracellular Applications.Nanomaterials (Basel, Switzerland) · 2024Review
- Nanoparticles for Interrogation of Cell Signaling.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023Review
- Appetizer on soft matter physics concepts in mechanobiology.Development, growth & differentiation · 2023Review
- Review
- Effects of forces on chromatin.APL bioengineering · 2021Review
- Influence of Environmental Parameters on the Stability of the DNA Molecule.Entropy (Basel, Switzerland) · 2021Article
- Modelling Nuclear Morphology and Shape Transformation: A Review.Membranes · 2021Review
- Interphase Chromatin Undergoes a Local Sol-Gel Transition upon Cell Differentiation.Physical review letters · 2021Article
- The rich inner life of the cell nucleus: dynamic organization, active flows, and emergent rheology.Biophysical reviews · 2020Review
- Structural and Dynamical Signatures of Local DNA Damage in Live Cells.Biophysical journal · 2020Article
- The self-stirred genome: large-scale chromatin dynamics, its biophysical origins and implications.Current opinion in genetics & development · 2020Review
- Viscoelastic Properties of ECM-Rich Embryonic Microenvironments.Frontiers in cell and developmental biology · 2020Article
- Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction.Frontiers in bioengineering and biotechnology · 2020Review
- Surface Fluctuations and Coalescence of Nucleolar Droplets in the Human Cell Nucleus.Physical review letters · 2018Article
- Applications, Surface Modification and Functionalization of Nickel Nanorods.Materials (Basel, Switzerland) · 2017Review
- Nuclear envelope: a new frontier in plant mechanosensing?Biophysical reviews · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The organization of chromatin in the cell nucleus is crucial for gene expression regulation. However, physically probing the nuclear interior is challenging because high forces have to be applied using minimally invasive techniques. Here, magnetic nanorods embedded in the nucleus of living cells are subjected to controlled rotational forces, producing micron-sized displacements in the nuclear interior. The resulting time-dependent rotation of the nanorods is analyzed in terms of viscoelastic parameters of the nucleus, in wild-type and Lamin A/C deficient cells. This method and analysis reveal that Lamin A/C knockout, together perhaps with other changes that result from the knockout, induce significant decreases in the nuclear viscosity and elasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.