ArticleRadiation oncology (London, England)2011
Clinical application of CT-guided (125)I seed interstitial implantation for local recurrent rectal carcinoma.
Article in Radiation oncology (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03890926 (The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy, a Retrospective Study), which is not on this map. Cited by 15 papers.
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The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy, a Retrospective Study
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Ultrasound-Guided Iodine-125 Seed Implantation for Cervical Metastatic Lymph Nodes: An Analysis of Efficacy and Safety.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Machine learning prognosis model for locally recurrent rectal cancer patients after radioactiveScientific reports · 2025Article
- The efficacy and dosimetry analysis of CT-guidedRadiation oncology (London, England) · 2020Article
- Permanent iodine-125 brachytherapy for patients with progressive or recurrent high-grade gliomas.BMC cancer · 2020Article
- Comparison of pre-implant treatment planning and post-implant dosimetry in I-125 spinal metastases brachytherapy.Oncology letters · 2020Article
- Long-Term Outcomes and Prognostic Analysis of Computed Tomography-Guided RadioactiveFrontiers in oncology · 2020Article
- Ultrasound-GuidedCancer biotherapy & radiopharmaceuticals · 2019Article
- CT-guided cryoablation for unresectable pelvic recurrent colorectal cancer: a retrospective study.OncoTargets and therapy · 2019Article
- Permanent Iodine-125 Seed Implantation for the Treatment of Nonresectable Retroperitoneal Malignant Tumors.Technology in cancer research & treatment · 2019Article
- The combination of systemic chemotherapy and local treatment may improve the survival of patients with unresectable metastatic colorectal cancer.Molecular and clinical oncology · 2017Article
- Clinical efficacy of computed tomography-guided iodine-125 seed implantation therapy in patients with advanced spinal metastatic tumors.OncoTargets and therapy · 2016Article
- Image-guided high-dose-rate brachytherapy: preliminary outcomes and toxicity of a joint interventional radiology and radiation oncology technique for achieving local control in challenging cases.Journal of contemporary brachytherapy · 2015Article
- Biological effects of low-dose-rate irradiation of pancreatic carcinoma cells in vitro using 125I seeds.World journal of gastroenterology · 2015Article
- Effectiveness and security of CT-guided percutaneous implantation of (125)I seeds in pancreatic carcinoma.The British journal of radiology · 2014Article
- Computed tomography-guided permanent brachytherapy for locoregional recurrent gastric cancer.Radiation oncology (London, England) · 2012Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study aimed to explore the safety profile and clinical efficacy of CT-guided radioactive seed implantation in treating local recurrent rectal carcinoma. MATERIALS AND
methodsCT-guided ¹²⁵I seed implantation was carried out in 20 patients with locally recurrent rectal carcinoma. 14 of the 20 patient had prior adjuvant external-beam radiation therapy (EBRT). The treatment planning system (TPS) was used preoperatively to reconstruct three dimensional images of the tumor and to calculate the estimated seed number and distribution. The median matched peripheral dose (MPD) was 120 Gy (range, 100-160 Gy).
resultsOf the 20 patients, 12 were male, 8 were female, and ages ranged from 38 to 78, with a median age of 62. Duration of follow-up was 3-34 months. The response rate of pain relief was 85% (17/20). Repeat CT scan 2 months following the procedure revealed complete response (CR) of the tumor in 2 patients, partial response (PR) in 13 patients, stable disease (SD) in 3 patients, and progressive disease (PD) in 2 patients. 75% of patients had either CR or PR. Median survival time was 18.8 months (95% CI: 3.5-22.4 months). 1 and 2 year survival rates were 75% and 25%, respectively. 4 patients died of recurrent tumor; 4 patients died of distant metastases; 9 patients died of recurrent tumor and distant metastases. 3 patients survived after 2 year follow up. Two patients were found to have mild hematochezia, which was reversible with symptomatic management.
conclusionCT-guided ¹²⁵I seed implantation appeared to be a safe, useful and less complicated interventional treatment option for local recurrent rectal carcinoma.
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