Evidence map›Paper›PMID 22004543›Full record

ReviewPediatric transplantation2011

Donor specific antibodies after transplantation.

Jeffrey L Platt, Marilia Cascalho

Open access · greenAbstract readReview
In one paragraph

Review in Pediatric transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Frontiers in immunology · 2020
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. The five dimensions of B cell tolerance.Immunological reviews · 2019
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. B cells in transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2016
    Article
  13. Single lung transplantation in a patient with retrospective positive cross-match.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2015
    Article
  14. Clinical impact of H-Y alloimmunity.Immunologic research · 2014
    Review
  15. Cryptic B cell response to renal transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013
    Article
  16. The paradoxical functions of B cells and antibodies in transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jeffrey L PlattDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109-2200, USA. plattjl@umich.edu
Marilia Cascalho
University of Michigan–Ann Arbor · US

Funding

T cell responses and cardiac transplantation in infancyP01HL079067 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2005 to 2009
$6.3M
Xenogeneic Natural Antibody Targets-Structure/FunctionR37HL052297 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2001 to 2010
$3.9M
XENOGENEIC NATURAL ANTIBODY TARGETS--STRUCTURE/FUNCTIONR01HL052297 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI PLATT, JEFFREY L · 1993 to 2000
$319k
NHLBI NIH HHS HL52297NHLBI NIH HHS HL79067NHLBI NIH HHS P01 HL079067NHLBI NIH HHS R01 HL052297NHLBI NIH HHS R37 HL052297
6 · The paper itself

Abstract

The detection of donor-specific antibodies after organ transplantation might provide an incisive way to monitor allo-specific immunity and predict graft outcome. Still, the availability of new assays for these antibodies prompts us to pose some questions about results that might be observed. These questions include whether the antibodies detected in the blood are a sensitive measure of alloimmunity, whether the detected antibodies are truly specific for the donor and whether they are noxious for the graft. Here, we explain why answers to these questions might interest the basic scientist and clinician.

Indexed as

AnimalsAntibodiesGraft RejectionGraft SurvivalHistocompatibility TestingHumansImmune SystemImmunity, HumoralInflammationIsoantibodiesKidney TransplantationPediatricsPerfusionPhenotypeTransplantationTransplantation, HeterologousAntibodiesIsoantibodies

Identifiers

PMID22004543
PMCPMC3196851
OpenAlexW1604731216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.