ArticleBMC complementary and alternative medicine2011
Antiurolithic activity of Origanum vulgare is mediated through multiple pathways.
Article in BMC complementary and alternative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Antiurolithic effects of medicinal plants: results of in vivo studies in rat models of calcium oxalate nephrolithiasis-a systematic review.Urolithiasis · 2021Pooled it
- Antibacterial activity of essential oils from Brocchia cinerea, Artemisia campestris and Origanum vulgare growing in Algeria against antibiotic-resistant foodborne pathogens.Scientific reports · 2026Article
- Struggling Thermal Stress Impacts on Growth Performance and Health Status of Newly Weaned Rabbits Using Nanoemulsion ofAnimals : an open access journal from MDPI · 2023Article
- Efficacy of a Multicomponent Nutraceutical Formulation for the Prevention and Treatment of Urinary Tract Stones.International journal of molecular sciences · 2023Article
- Antiurolithiasis activities ofAmerican journal of clinical and experimental urology · 2023Article
- Acute Toxicity of Dental Gel Based onJournal of toxicology · 2023Article
- Chemical Composition, Antioxidant Potentials, and Calcium Oxalate Anticrystallization Activity of Polyphenol and Saponin Fractions fromPlants (Basel, Switzerland) · 2022Article
- The antiurolithic activity ofCurrent urology · 2021Article
- Nephroprotective Effect ofBiomolecules · 2020Article
- Article
- Protective potential of Angelica sinensis polysaccharide extract against ethylene glycol-induced calcium oxalate urolithiasis.Renal failure · 2018Article
- Article
- Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms.International journal of molecular sciences · 2018Review
- The Confrontation between Ethnopharmacology and Pharmacological Tests of Medicinal Plants Associated with Mental and Neurological Disorders.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Molecular mechanisms involved in the protective effect of the chloroform extract of Selaginella lepidophylla (Hook. et Grev.) Spring in a lithiasic rat model.Urolithiasis · 2013Article
- Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica.Urological research · 2012Article
- Antiurolithiatic and antioxidant efficacy ofIndian journal of pharmacologyArticle
- Evaluation of Antiurolithiatic Effects ofDose-response : a publication of International Hormesis SocietyArticle
- Antilithiatic Activity of phlorotannin rich extract of Sarghassum Wightii on Calcium Oxalate Urolithiais - InVitro and In Vivo Evaluation.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Progress and prospects in the management of kidney stones and developments in phyto-therapeutic modalities.International journal of immunopathology and pharmacologyReview
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundOriganum vulgare Linn has traditionally been used in the treatment of urolithiasis. Therefore, we investigated the crude extract of Origanum vulgare for possible antiurolithic effect, to rationalize its medicinal use.
methodsThe crude aqueous-methanolic extract of Origanum vulgare (Ov.Cr) was studied using the in vitro and in vivo methods. In the in vitro experiments, supersaturated solution of calcium and oxalate, kidney epithelial cell lines (MDCK) and urinary bladder of rabbits were used, whereas, in the in vivo studies, rat model of urolithiasis was used for the study of preventive and curative effect.
resultsIn the in vitro experiments, Ov.Cr exhibited a concentration-dependent (0.25-4 mg/ml) inhibitory effect on the slope of nucleation and aggregation and also decreased the number of calcium oxalate monohydrate crystals (COM) produced in calcium oxalate metastable solutions. It also showed concentration-dependent antioxidant effect against DPPH free radical and lipid peroxidation induced in rat kidney tissue homogenate. Ov.Cr reduced the cell toxicity using MTT assay and LDH release in renal epithelial cells (MDCK) exposed to oxalate (0.5 mM) and COM (66 μg/cm(2)) crystals. Ov.Cr relaxed high K(+) (80 mM) induced contraction in rabbit urinary bladder strips, and shifted the calcium concentration-response curves (CRCs) towards right with suppression of the maximum response similar to that of verapamil, a standard calcium channel blocker. In male Wistar rats receiving lithogenic treatment comprising of 0.75% ethylene glycol in drinking water given for 3 weeks along with ammonium chloride (NH(4)Cl) for the first 5 days, Ov.Cr treatment (10-30 mg/kg) prevented as well as reversed toxic changes including loss of body weight, polyurea, crystalluria, oxaluria, raised serum urea and creatinine levels and crystal deposition in kidneys compared to their respective controls.
conclusionThese data indicating the antiurolithic activity in Ov.Cr, possibly mediated through inhibition of CaOx crystallization, antioxidant, renal epithelial cell protective and antispasmodic activities, rationalizes its medicinal use in urolithiasis.
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