ArticleBehavioral neuroscience2012
Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats.
Article in Behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Bisphenol A and human fertility: a systematic review.JBRA assisted reproduction · 2025Pooled it
- Protective effects of gastrodin against bisphenol A-induced dopaminergic dysregulation and cognitive impairment in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Taurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer's disease-like pathology through Akt-ERK crosstalk pathway in male rats.Psychopharmacology · 2025Article
- Central Causation of Autism/ASDs via Excessive [CaBrain sciences · 2024Review
- Potential neuroprotective effect of nanomicellar curcumin on learning and memory functions following subacute exposure to bisphenol A in adult male rats.Metabolic brain disease · 2023Article
- Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo.Biology · 2023Article
- Hippocampus-based behavioral, structural, and molecular dynamics across the estrous cycle.Journal of neuroendocrinology · 2023Review
- Developmental Exposure to Bisphenol a Degrades Auditory Cortical Processing in Rats.Neuroscience bulletin · 2022Article
- Sex differences in cognition following variations in endocrine status.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Review
- Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex.Disease models & mechanisms · 2022Article
- Does Bisphenol A Confer Risk of Neurodevelopmental Disorders? What We Have Learned from Developmental Neurotoxicity Studies in Animal Models.International journal of molecular sciences · 2022Review
- Article
- Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.Journal of neuroinflammation · 2020Article
- Protective effect of crocin on bisphenol A - induced spatial learning and memory impairment in adult male rats: Role of oxidative stress and AMPA receptor.Iranian journal of basic medical sciences · 2020Article
- Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability.International journal of environmental research and public health · 2019Review
- Structural plasticity of the hippocampus in response to estrogens in female rodents.Molecular brain · 2019Review
- Review
- Neuro-toxic and Reproductive Effects of BPA.Current neuropharmacology · 2019Review
- Rapid effects on memory consolidation and spine morphology by estradiol in female and male rodents.Hormones and behavior · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Exposure to Bisphenol-A (BPA), an endocrine disruptor used in plastics, occurs in the United States on a daily basis. Recent studies suggest exposure during development causes memory deficits later in life; however, the ramifications of exposure in adulthood are unclear. We examined the effects of acute BPA administration (40 μg/kg) on memory and synaptic plasticity in adult male rats. BPA significantly impaired both visual and spatial memory and decreased dendritic spine density on pyramidal cells in CA1 and the medial prefrontal cortex (mPFC). Additionally, BPA significantly decreased PSD-95, a synaptic marker, in the hippocampus and increased cytosolic pCREB, a transcription factor, in mPFC. Together, these findings show that a single dose of BPA, below the USEPA reference safe daily limit of 50 μg/kg/day, may block the formation of new memories by interfering with neural plasticity processes in the adult brain.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.