ArticleACS nano2011
125I-labeled gold nanorods for targeted imaging of inflammation.
Article in ACS nano, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
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- Trastuzumab-Modified Gold Nanoparticles Labeled withNanomaterials (Basel, Switzerland) · 2019Article
- Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α.Heart and vessels · 2019Article
- Hypothalamic Inflammation at a Crossroad of Somatic Diseases.Cellular and molecular neurobiology · 2019Review
- Applying nanomedicine in maladaptive inflammation and angiogenesis.Advanced drug delivery reviews · 2017Review
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- Chemisorption of iodine-125 to gold nanoparticles allows for real-time quantitation and potential use in nanomedicine.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2017Article
- Plasmonic Nanoparticles with Quantitatively Controlled Bioconjugation for Photoacoustic Imaging of Live Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Biodistribution and fate of core-labeledJournal of materials chemistry. B · 2016Article
- Evaluation of therapeutic effectiveness of (131)I-antiEGFR-BSA-PCL in a mouse model of colorectal cancer.World journal of gastroenterology · 2016Article
- Quantitatively Understanding Cellular Uptake of Gold Nanoparticles via Radioactivity Analysis.Journal of nanoscience and nanotechnology · 2015Article
- Neuroinflammation after intracerebral hemorrhage.Frontiers in cellular neuroscience · 2014Review
- Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation.ACS nano · 2013Article
- Perspectives on clinical translation of smart nanotherapeutics.Therapeutic delivery · 2012Article
- Emerging role of radiolabeled nanoparticles as an effective diagnostic technique.EJNMMI research · 2012Article
- Noninvasive molecular imaging of neuroinflammation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
For better examination of inflammation, we designed inflammation-targeted nuclear and optical dual-modality contrast agents prepared by I-125 radiolabeling of gold nanorods (GdNRs) conjugated with anti-intercellular adhesion molecule 1 (ICAM-1) antibody. The bioactivity and specific binding of the PEGylated (125)I-ICAM-GdNR conjugates to the ICAM-1 was validated through ELISA testing. Inflammation-targeted imaging was then conducted on an adjuvant-induced arthritic rat model which demonstrated an elevation of ICAM-1 level in the affected ankle joints. Facilitated by the I-125 radioisotope and the whole-body imaging via the Gamma camera, the time-dependent distribution of the systemically injected agent as well as the uptake of the agent in the inflammatory articular tissues could be examined conveniently and quantitatively. The success in targeted delivery of gold nanoparticles to inflammatory tissue enables both nuclear and optical imaging of inflammation at molecular or cellular level. Other than diagnosis, radiolabeled gold nanoparticles also hold promise for targeted therapy of a variety of disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.